实验性神经起步点自发放电的分叉和整数倍节律  

THE BIFURCATION AND INTEGER MULTIPLE SPIKING IN THEEXPERIMENTAL NEURONAL PACEMAKERS

作　　者：古华光 任维[1] 陆启韶[2] 杨明浩[1] 

机构地区：[1]航天医学工程研究所,北京100094 [2]北京航空航天大学理学院,北京100083

出　　处：《生物物理学报》2001年第4期637-644,共8页Acta Biophysica Sinica

基　　金：国家自然科学基金 (39270247)资助项目

摘　　要：在实验性神经起步点发现了放电峰峰间期序列随细胞外[Ca2 +]变化产生的加周期分叉和整数倍节律。并用确定性Chay模型和随机Chay模型进行数值模拟。从模拟实验结果的角度看 ,加周期分叉过程遵从Chay模型决定的确定性机制 ,随机因素对其有影响但影响较小 ;而在相应的参数区间 ,整数倍节律则是在随机因素驱动下产生 ,是随机共振现象 ,是由确定性机制和随机因素共同作用的结果。这表明 :实验性神经起步点放电节律的分叉和随机共振现象的出现是必然的 ,受确定性机制和随机因素共同影响。但在不同参数区间 。The period-adding bifurcation and the integer multiple spiking were observed in the experiments on the neuronal pacemakers when the extracellar concentrations of Ca2+ was changed. And the numerical simulation was done through both the deterministic model and the stochastic model. The results show that the period-adding bifurcation obeys the deterministic mechanism decribed by Chay model and lightly affected by stochastic factors. In the corresponding parameter region, the integer multiple spiking generates only when the stochastic factors are introduced to the model. The phenomenon is autonomous stochastic resonance. The generation of the integer multiple spiking is the interaction between the deterministic mechanism and the stochastic factors. The results revealed that the generation of the bifurcation and stochastic resonance is natural. It obeys the deterministic mechanism and is influenced by the stochastic factors, which play different roles in different parameter region.

关 键 词：神经元 自发放电 分叉 随机自共振 节律 动作电位间期 神经起步点 整数倍节律 

分 类 号：Q424[生物学—神经生物学]