乙型流行性感冒病毒两大谱系的起源及其演变特征  

The Origin and Evolution of Two Genetic Lineages of Influenza B Virus

作　　者：陈继明[1] 郭元吉[1] 吴昆昱[1] 郭俊峰[1] 

机构地区：[1]中国预防医学科学院病毒学研究所国家流感中心,北京100052

出　　处：《病毒学报》2001年第4期322-327,共6页Chinese Journal of Virology

摘　　要：测定 1972～ 2 0 0 0年间在中国分离并保存的乙型流行性感冒 (流感 )病毒一些毒株的HA1区核苷酸序列 ,结合GenBank中其它毒株的相关序列以及流行病学资料进行分析 ,结果提示 ,当前在世界上流行的乙型流感病毒两大谱系起源于 2 0世纪 70年代中期 ,而不是以前推测的 6 0年代末 ,并且其中一个谱系起源于中国。结果还提示 ,乙型流感病毒的演变同时受到很强的正选择与负选择的作用 ,而以前人们认为选择对乙型流感病毒的演变作用甚微。还修正了乙型流感病毒变异速率的计算方法。The nucleotide sequences of HA1 regions of some of the influenza B viruses isolated from 1972-2000 in China were tested and analyzed with the corresponding sequences of viruses previously reported as well as with their epidemic records.Results showed that the divergence of two main influenza B virus lineages began in mid-1970s,but not at the end of 1960s as previously suspected.Results also showed that the evolution of influenza B virus was under both strong positive selection and negative selection,which was contrary to previous reports.Calculation of the variation rate of influenza B virus was revised in this paper.

关 键 词：乙型流行性感冒病毒 进化 流行病学 选择 变异速率 

分 类 号：R373.13[医药卫生—病原生物学]