309例药源性尿潴留的文献分析  

Analysis of 309 cases with drug- induced urinary retention (DIUR)

作　　者：杨劲松[1] 郭利民[1] 肖科武[1] 艾雄[1] 

机构地区：[1]益阳市中心医院,湖南益阳413000

出　　处：《药物不良反应杂志》2001年第2期83-86,共4页Adverse Drug Reactions Journal

摘　　要：目的:了解药物导致药源性尿潴留的情况。方法:对1988～1999年《中国药学文摘》、《中国生物医学文摘》、《中国生物医学光盘数据库》中文期刊中的309例药源性尿潴留病例进行文献分析。结果:最易引起药源性尿潴留的药物为镇痛药,占32.4％,其次为心血管药及抗感染药,分别占16.8％,11.7％;出现频率较高的药物为吗啡(79例)、硝苯地平(30例)。此外,性别、年龄、用药行为及剂量等也是导致药源性尿潴留的因素。结论:合理用药至关重要,以减少药源性尿潴留的发生。Objective: To review the cases with DIUR in recent years.Methods: Chinese Pharmaceutical Abstract, Chinese Biomedical Abstract and CMSS Database of 1988 - 1999 were retrieved with an analysis of 309 DIUR cases.Results: On the list of DIUR high frequency analgetics ranked first (32.4%) followed by cardiovascular drugs (16.8%) and anti - infectives (11.7%) . Morphine and nifedipine were among the top drugs for urinary retention, leading to 79 and 30 cases respectively. In addition, sex, age, the way of drug administration and drug dose were the considerable factors, too.Conclusion: Rational use of drugs is suggested in order to reduce DIUR.

关 键 词：药源性尿潴留 药物不良反应 文献分析 药源性疾病 

分 类 号：R181.35[医药卫生—流行病学]