卡托普利不能抑制激素对大鼠阿霉素肾病肾小球硬化的恶化作用  

Captopoil can not Block the Accelcrated Effects of Corticostoroids on Glomorulosclerosis in rats with adriamycine nephropathy

作　　者：崔世维[1] 潘正平[1] 邵亚男[1] 钱桐荪[1] 

机构地区：[1]南通医学院附属医院,南通226001

出　　处：《中国中西医结合肾病杂志》2001年第12期692-694,701,共4页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：江苏省科学技术委员会资助项目 (No .90 0 18)

摘　　要：目的 :探讨血管紧张素转换酶抑制剂 (ACEI)卡托普利能否抑制肾上腺糖皮质激素 (激素 )对大鼠阿霉素肾病肾脏病理损害的加重作用。方法 :40只SD雄性大鼠分成A(正常对照 )组、B(阿霉素 )组、C(阿霉素 +泼尼松 )组和D(阿霉素 +泼尼松 +卡托普利 )组。注射阿霉素后 4周开始经饮水给予入泼尼松及卡托普利 ,其浓度分别为 5 0mg/dl和 2 5mg/dl。在注射阿霉素之后的第 16周及 2 8周末每组分别用 5只大鼠取血及肾脏组织 ,分别作生化及病理检查。结果 :注射阿霉素 1周以后尿蛋白 (Upro)开始升高 ,4周以后达到 (16 8.45± 76 .2 8)mg/d。B组、C组及D组注射阿霉素后第 16周末及 2 8周末Upro、血清肌酐 (Scr)、甘油三酯 (Trg)及血清总胆固醇 (ChL)都显著高于A组 ,血清白蛋白 (Salb)则显著低于A组。B组、C组及D组组内第 2 8周与第 16周比较 ,Upro、Scr升高有显著性差异 ,Salb降低有显著差异。C组与B组比较 ,Upro、Scr、Trg及ChL显著升高。而D组上述生化指标的变化与C组比较都无显著性差异。B组肾脏病理积分显著高于A组 ,且第 2 8周末显著高于第 16周末 ;C组及D组第 16周末肾脏病理积分显著高于B组 ,但D组与C组比较无显著差异。结论Objectives:The aim here was to identify whether or not the angiotensin converting enzyme inhibitor(ACEI) captopril can restrain the deterioration effects of glucosteriod on rat adriamycine nephropathy.Methods:Forty male SD rats were randomly divided into four groups: (1) normal control(Group A),(2)treatment with adriamycin(Group B),(3)treatment with adriamycin plus prednisone (Group C) and (4) treatment with adriamycin plus prednisone and captopril(Group D). The administration of drugs begun on the fourth weekend after the injection of adriamycin(7 mg/kg) and continued for all the study duration. prednisone and captopril were given in drinking water in the concentrations of 50 mg/dl and 25 mg/dl respectively. On the sixteenth and 28th weekends after injection of adriamycin blood sample and renal tissue were obtained in 5 rats of each group for the biochemical and pathological tests.Results:Urine protein excretion rate(Upro) was significantly eleveted 1 week within adriamycin administration, and reached the level of (168.45±76.28) mg/day more 4 weeks later. On the 16th and 28th weekends respectively, Upro, serum creatinine(Scr), triglyceride(Trg) and total cholesterol(ChL) level of group B, group C and group D were significantly higher and serum albumin(Salb) level was significantly lower than those of group A respectively. On the 28th weekend both Upro, Scr levels were significantly higher and Salb level was significantly lower than those on 16th weekend of group B, group C and group D. The Upro, Scr, Trg and ChL of group C were significantly higher than those of group B. There was no significant difference between group D and group C on the 16th weekend in any biochemical test result. Marked renal histopathologic damage of group B was observed when compared with group A, and it was more severe on the 28th weekend in group B. On the 16th weekend the renal damage of group C and group D were more severe than that of group B. There was no significant difference between group D and group C in the degree of re

关 键 词：肾上腺糖皮质激素 肾小球肾炎 肾病综合征 NS 阿霉素 肾小球硬化 蛋白尿 

分 类 号：R965[医药卫生—药理学]