六味地黄丸协同必可酮对致敏豚鼠气道反应性及血嗜酸细胞的影响  

EFFECT OF LIU WEI DIHUAN WAN PILLS AND BECLOMETHASONE DIPROIONATE AEROSOL ON REACTIVITY OF THE AIR PASSAGE AND BLOOD EOSINOPHILIC GRANULOCYTE IN THE ALLERGY- INDUCED GUINEA PIGS

作　　者：王力宁[1] 李伟伟[1] 李伟芳[2] 韦宝伟[2] 

机构地区：[1]广西中医学院第一临床医学院,南宁市园湖路2号530023 [2]广西中医药研究所,530022

出　　处：《广西中医药》2001年第6期51-53,共3页Guangxi Journal of Traditional Chinese Medicine

基　　金：广西自然科学基金资助项目(9912031);广西卫生厅重点资助项目(重200010)

摘　　要：目的 :探讨滋阴补肾法合吸入糖皮质激素对致敏豚鼠气道反应性及外周血嗜酸性粒细胞的影响。方法 :除正常动物对照组外 ,5个给药组均以卵蛋白福氏不完全性佐剂腹腔注射致敏 ,卵蛋白生理盐水鼻腔注入激发 ,建立哮喘模型。从致敏的同一天开始 ,给药组必可酮喷雾给药 ,六味地黄丸灌胃给药 ,正常组和模型组灌服蒸馏水。分别测各组豚鼠外周血的嗜酸性粒细胞 ;用卵蛋白乐氏液从气管注入作体外激发 ,测支气管肺灌流速度。结果 :六味地黄丸加不同剂量必可酮组的致敏豚鼠肺支气管灌流平均流速均比哮喘模型对照组、必可酮组和六味地黄丸组高 ,其差异均具有显著性意义(P<0 05)。六味地黄丸加不同剂量必可酮剂量组的外周血嗜酸性粒细胞均比哮喘模型对照组、必可酮组和六味地黄丸组低 ,其差异均具有显著性意义(P<0 05)。结论 :六味地黄丸具有协同必可酮减轻气道炎症。Purpose: To study the effect of Liu Wei Dihuan Wan Pills and Beclomathasone Diproionate Aerosol (BDA) on reactivity of the air passage and blood eosinophilic granulocyte in the allergy- induced guinea pigs. Methods: Except the normal control group, all the other 5 groups were given injection into the abdominal cavity with the BDA to induce allergy reaction. Then the normal saline of egg alumin was injected into nasal cavity for excitation to prepare the asthma model group. From the day of the allergy reaction, some pigs were sprayed with BDA to prepare the BDA group, and some were perfused into the stomach with Liu Wei Dihuan Wan Pills to prepare another group. And the normal control group and the asthma model group were perfused with distill water. Then the peripheral blood eosinophilic granulocyte was determined. Also the egg alumin BDA was injected into the air passage for excitation in vitro so as to test the broncho- pulmonary perfusion flow. Results: The broncho- pulmonary perfusion flow in the guinea pigs given Liu Wei Dihuan Wan Pills and different dosages of BDA was higher than that in the asthma model group, the BDA group and the group with only Liu Wei Dihuan Wan Pills, with significance being great (P<0.05). Furthermore, the peripheral blood eosinophilic granulocyte in the group given Liu Wei Dihuan Wan Pills and different dosages of BDA was lower than that in the asthma model group, the BDA group and the group given Liu Wei Dihuan Wan Pills with greatly different significance (P<0.05). Conclusions: Liu Wei Dihuan Wan Pills plus BDA can alleviate inflammation in the air passage, lower the reactivity of the air passage and blood eosinophilic granulocyte.

关 键 词：哮喘 气道反应性 嗜酸性粒细胞 滋阴补肾法 中西医结合治疗 六味地黄丸 必可酮 

分 类 号：R562.250.5[医药卫生—呼吸系统] R285.6[医药卫生—内科学]