血清sFas、sFasL水平与特发性血小板减少性紫癜的关系  

The study of the serum level of soluble Fas and soluble Fas ligand in ldiopathic thrombocytopenic purpura

作　　者：刘晓莉[1] 张茂宏[1] 彭军[1] 

机构地区：[1]山东大学齐鲁医院,山东济南250012

出　　处：《山东医药》2001年第22期11-12,共2页Shandong Medical Journal

摘　　要：采用酶联免疫夹心法 (EL ISA)检测了 2 5例特发性血小板减少性紫癜 (ITP)患者血清中 s Fas、s Fas L的水平。结果显示 ITP患者血清 s Fas含量为 16 .5 1± 6 .86μg/ L ,s Fas L含量为 0 .48± 0 .33μg/ L ,均显著高于正常对照 (分别为 P<0 .0 0 1和 P<0 .0 1) ;18例 ITP患者血清 s Fas水平升高 ,其中有 9例同时有 s Fas L水平升高 ,但是血清 s Fas水平升高组的血小板计数与 s Fas正常组无显著差异。提示 s Fas和 s Fas LIn order to assess the clinical significance of soluble Fas(sFas)and soluble Fas ligand(sFasL)in the sera of patients with idiopathic thrombocytopenic purpura(ITP), the serum levels of sFas and sFasL in 25 patients with ITP were determined by a sandwich enzyme linked immunosorbent assay ( ELISA). The serum levels of sFas and sFasL in patients with ITP were 16.51±6.86μg/L and 0.48±0.33μg/L respectively. Both of them are significantly higher than that of normal control ( P<0.001, P<0.01 respectively). The serum level of sFas in 18 patients was increased. The level of sFasL in 9 of 18 patients increased accompanied with sFas. However, the high level of sFas was not correlated with the platelet counts. The result suggests that the aberration of sFas and sFasL is involved in the immunological pathogenesis of ITP.

关 键 词：紫癜 细胞凋亡 可溶性FAS 可溶性FASL 特发性血小板减少性紫癜 

分 类 号：R554.6[医药卫生—血液循环系统疾病]