外源性一氧化氮和氦氧混合气体对健康成人气道的调控作用  

The effect of inhaled nitric oxide and helium-oxygen mixture on the airway of healthy man

作　　者：马迎民[1] 刘又宁[1] 郝峰英[1] 朴哲龙[1] 

机构地区：[1]解放军总医院呼吸科,北京100853

出　　处：《军医进修学院学报》2001年第4期311-314,共4页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的 :探讨一氧化氮 (NO)和低密度气体—氦氧混合气 (Heliox)对健康成人气道激发后的作用。方法 :选择健康成年非吸烟男性 12名作为受试者 ,吸入乙酰甲胆碱 (Mch) ,激发气道。受试者坐位 ,带鼻罩 ,通过呼吸机自主呼吸。实验分三阶段进行 ,即气道激发后吸入空气 ;激发后吸入氦氧混合气和同时吸入一氧化氮及氦氧混合气。检测用力肺活量 (FVC)、第一秒用力呼气量 (FEV1)和用力呼气中期流速 (MMF)。结果 :气道激发后 ,三组的FEV1均显著下降 ,与基础值比较差异有显著意义 (P <0 0 5 )。在吸入氦氧混合气期间FEV1和MMF值高于吸入空气组 ,差异有显著意义。吸入Heliox的同时加入NO能使FEV1进一步提高 ,但不能进一步改善MMF。与空气组相比 ,吸入Heliox组及吸入Heliox时加入NO ,FVC有增加趋势。结论 :本研究结果提示 ,高浓度的NO虽然能对抗乙酰甲胆碱引起的气道收缩 ,但作用较弱。而氦氧混合气对大小气道均有作用 ,其改善通气功能的作用明显强于NO ,临床应用前景广阔。Objective:To evaluate the effect of inhaled nitric oxide (NO) and Helium Oxygen mixture (Heliox) on the airway of healthy bronchoprovocation man Methods: 12 healthy non smoking men were included in this research The bronchoconstriction of the subject was induced by inhaled methacholine The man sat and breathed with a nasal mask through a mechanical ventilator The research course was divided into the following three steps Inhalation of air after bronchoconstriction; inhalation of Heliox; and inhalation of NO and Heliox The FVC, FEV 1 and MMF were monitored during the research Results: After bronchoprovocation challenged, FEV 1 and MMF decreased significantly Comparing with the inhalation of air, FEV 1 and MMF increased during the inhalation of Heliox FEV 1 can be increased more when NO was put in Heliox But MMF was not changed FVC was only increased slightly during the inhalation of Heliox or the inhalaton of Heliox and NO simultaneously Conclusion:The study suggested that the high dose of NO can resist the brochoconstriction, but the effect was insufficient The effect of Heliox on airway is stronger than NO, because Heliox can influence either the large airway or the small airway

关 键 词：一氧化氮 气道阻力 氦氮混合气体 哮喘 

分 类 号：R332.2[医药卫生—人体生理学] R562.25[医药卫生—基础医学]