急性有机磷中毒患者血浆甲状腺激素水平的动态变化及意义  

Clinical significance of changes of plasma thyroid hormone concentrations in patients with AOPP

作　　者：李春凤[1] 郭小刚[2] 杨蕾[1] 梁东良[1] 赵金垣[3] 

机构地区：[1]新乡医学院第一附院急救中心,河南卫辉453100 [2]华新纱厂职工医院 [3]北京医科大学第三临床医学院

出　　处：《中国急救医学》2001年第10期584-585,共2页Chinese Journal of Critical Care Medicine

基　　金：国家"九五"攻关课题 (国家科委编号 96-90 6-0 4-11)临床研究部分内容

摘　　要：目的　探讨有机磷中毒患者血浆甲状腺激素 (TH)的变化及其临床意义。方法　应用放射免疫分析法测定 6 0例有机磷中毒 (AOPP)患者和 5 8例健康人 (对照组 )的血浆TH含量。结果　中度有机磷中毒患者血浆T3 及重度有机磷中毒患者血浆T3 、T4 含量在中毒后第 1天和第 3天明显低于对照组 (P <0 0 5或P <0 0 0 1) ,T3 含量在中、重之间相比较有显著差异 (P <0 0 5 ) ,rT3 含量在中毒后第 3天较对照组升高 (P <0 0 5 ) ,T3 、T4 、rT3 第 7天均恢复正常 (死亡患者除外 ) ,血浆TSH水平中毒组和对照组无差异。结论　监测有机磷中毒患者血浆TH水平可作为反映病情程度和评估预后的一项参考指标。Objective To valuate the clinical significance changes of plasma thyroid hormone (TH)of patients with acute organ phosphorus pesticide (AOPP)intoxication.Methods Plasma TH concentrations were measured in 60 patients with AOPP and 58 healthy volunteers (control group)by vodioimmunoassay.Results Plasma T 3 concentrations on moderate AOPP and T 3/T 4 concentrations on serious AOPP patients were markedly lower than control group on first day and third day ( P <0.05 or P <0.001),the level of T 3 and T 4 were different significantly between moderate group and serious group ( P <0.05)respectively,rT 3 concentration were higher than control group on third day.PlasmaT 3?T 4?rT 3 were normal on seventh day.There were no obvious difference of plasma TSH level between AOPP patients and control group ( P >0 05) Conclusions Measurement of plasma TH may be a useful parameter to predict severity and outcome of the illness.

关 键 词：有机磷农药 甲状腺激素 急性有机磷中毒 血浆 

分 类 号：R595.4[医药卫生—内科学]