人型支原体对药物敏感性的研究  

Susceptibility of Mycoplasma Hominis to Several Antimicrobials and Chinese Medicinal Herbs

作　　者：车雅敏[1] 毛舒和[2] 缴稳苓[1] 梁健[2] 杨新建[2] 寇欣[2] 刘雅男[2] 陈锦英[1] 刘全中[1] 傅志宜[1] 

机构地区：[1]天津医科大学总医院皮肤科,300052 [2]天津市长征医院

出　　处：《中华皮肤科杂志》2001年第6期420-422,共3页Chinese Journal of Dermatology

基　　金：天津市卫生局资助项目(项目编号:98KY-46)

摘　　要：目的研究泌尿生殖道人型支原体(Mh)对中西药物的敏感性。方法在Mh培养法的基础上,建立液体微量稀释法测定32株Mh对11种抗菌药物的最小抑菌浓度(MIC),并测定30株Mh对19种中药的MIC。结果Mh对11种抗菌药物的敏感性由高到低依次为:林可霉素、四环素、米诺环素、左旋氧氟沙星、环丙沙星、氧氟沙星、利福平、螺旋霉素、阿奇霉素、琥乙红霉素和红霉素。在19种中药中,Mh对板兰根、黄柏和白芷有较高敏感性,对大黄、鱼腥草和地肤子有中度敏感性,对其余13种中药不敏感。结论了解了本地区Mh对临床上常用抗菌药物的敏感性和耐药情况,首次筛选出6种Mh较敏感的中药,为中西医结合治疗Mh感染提供了依据。Objective To study the susceptibility of Mycoplasma hominis(Mh) to several antimicrobials and Chinese medicinal herbs. Methods The minimal inhibitory concentrations(MIC) of Mh to 11 antimicrobials and 19 herbs were detected by the method of liquid microdilution. Results The sensitivity of Mh to those antimicrobials from high to low, was as follows:lincomycin, tetracycline, minocycline, levofloxacin, ciprofloxacin, ofloxacin, rifampin, spiramycin, azithromycin, erythromycin ethyl succinate and erythromycin. Among 19 herbs,Mh was sensitive to Radix Isatidis, Radix Angelicae Dahuricae, Cortex Phellodendri, Rheam Officinale, Fructus Kochiae and Herba Houttuyniae. Conclusions The susceptibility of local isolates of Mh to common antimicrobials is found out. Six Mh sensitive Chinese medicinal herbs are screened. The study provides evidences of treating Mh infection by combination of antimicrobials with Chinese medicinal herbs.

关 键 词：敏感性试验 抗生素类 中草药 人型支原体 中西医结合治疗 泌尿生殖系疾病 

分 类 号：R446.5[医药卫生—诊断学]