白癜风患者血浆与皮肤组织液β-内啡肽水平测定  

Plasma and Skin Tissue Fluid Levels of beta-endorphin in Patients with Vitiligo

作　　者：赵达明[1] 高明阳[1] 涂彩霞[1] 

机构地区：[1]辽宁省大连医科大学附属第一医院皮肤科

出　　处：《中华皮肤科杂志》2001年第6期430-431,共2页Chinese Journal of Dermatology

基　　金：辽宁省科委课题(972290)

摘　　要：目的探讨β-内啡肽在白癜风发病中的作用。方法以125I放免药盒检测了40例白癜风患者血浆及其中33例患者皮肤组织液β-内啡肽水平。结果白癜风泛发型(11.74±3.47pmol/L,以下单位同)、局限型(8.31±2.57)与节段型(8.61±2.61)患者血浆β-内啡肽水平明显高于正常对照组(6.69±1.46)。局限型与节段型白癜风皮损处皮肤组织液β-内啡肽水平(分别为9.25±4.49,10.24±4.37)明显高于非皮损处(分别为5.50±2.84,6.12±1.61)。泛发型患者皮损处与非皮损处组织液β-内啡肽水平均有升高,二者差异无显著性。结论β-内啡肽可能在白癜风的发病过程中起一定作用。Objective To study the role of beta endorphin (β-EP) in the pathogenesis of vitiligo. Methods Radioimmunoassay (RIA) was used to measure the levels of β-EP in plasma from 40 patients and tissue fluid of lesional and non lesional skin from 33 patients with vitiligo. Results Plasma levels of β-EP were significantly higher in patients with generalized(11.74±3.47 pmol/L), local(8.31±2.57) and segmental(8.61±2.61) vitiligo than those in normal controls(6.69±1.46). Tissue fluid levels of β-EP were significantly higher in lesional skin (9.25±4.49 and 10.24±4.37) than those in non lesional skin (5.50±2.84 and 6.12±1.61) from patients with local and segmental vitiligo. Increased levels of β-EP were observed in tissue fluid from both lesional and non lesional skin in patients with generalized vitiligo, however, no significant difference of β-EP levels was found between the two kinds of skin tissue. Conclusion It is suggested that β-EP might play a role in the pathogenesis of vitiligo.

关 键 词：白癜风 Β内啡肽 血浆 皮肤组织液 测定 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]