大鼠虚热证模型的研制  

Development of Animal Model of Heat syndrome Due to Insufficiency of Yin Fluids

作　　者：周永生[1] 樊雅莉[1] 张宇鹏[1] 蒋小丽[1] 邹世洁[1] 崔成德[1] 乔文彪[2] 陈小野[1] 邵德彬[1] 王肃[1] 王丽芳[1] 

机构地区：[1]中国中医研究院,北京100700 [2]陕西中医学院中基教研室,陕西西安710049

出　　处：《中国中医基础医学杂志》2001年第9期23-26,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家科技部条财司"九五"项目 (NO TJ99 LA0 1) ;北京市科委实验动物专项资金基金 (NO 95 49812 0 0 )

摘　　要：目的 :改进现行的虚热证动物模型。方法 :6到 8倍以往造模量的中药通过灌胃给予动物 ,灌胃时间为 2 8d。在实验过程的不同时间对大鼠的外观、舌象、大便、受激排便等进行观察 ,并测定大鼠的体温、食量、饮水量、游泳时间以及某些脏器指数和与虚热证有关的生物化学指标。结果 :大鼠不但有热证表现 ,而且有一定的虚证表现。结论 :这种诱发虚热证的方法具有一定的优点 ,但仍可进一步改进。Objective:To improve the present animal model of heat syndrome due to insufficiency of Yin fluids.Methods:Decoction of Chinese herbal drugs that induce heat sydrome due to insufficiency of Yin fluids was administered to the rats for 28 days in 6～8 times dosage used in the previous experiments,and the appearances,picture of tongue,stool,and stimulated defecation were observed and organ indexes(wet weight of organ/body weight)of some organs,body weight,temperature,food and drink amount,swimming duration,and the biochemical indexes related to heat syndrome due to insufficiency of Yin fluids were determined at different time.Results:The rats had the manifestations of heat syndrome,as well as the manifestations of deficiency syndrome in varying degrees.Conclusion:This method of developing heat syndrome due to insufficiency of Yin fluids has some advantages,however,it needs to be further improved.

关 键 词：虚热证 精气夺 虚证 疾病模型 

分 类 号：R241.3[医药卫生—中医诊断学]