清肝利湿汤对兔胆囊炎胆石症模型肿瘤坏死因子的影响  

Effect of Qi-Gan-Li-Shi(QGLS)Decoction on Tumor Necrosis Factor in Rabbits of Cholecystitis and Choleithiasis

作　　者：喻长远[1] 李家邦[1] 田永立[1] 

机构地区：[1]中南大学湘雅医院中西医结合研究所,湖南长沙410008

出　　处：《中国中医基础医学杂志》2001年第9期38-40,共3页JOURNAL OF BASIC CHINESE MEDICINE

摘　　要：目的 :探讨清肝利湿汤对兔胆囊炎胆石症模型血浆及胆囊局部肿瘤坏死因子 α(TNF α)含量的影响。方法 :将 4 0只家兔随机分为空白对照组、模型对照组、龙胆泻肝汤组及清肝利湿汤组 ,每组 10只。除空白对照组外 ,其余 3组均手术造模。空白对照组及模型组插胃管灌蒸馏水 ,余 2组分别插胃管灌药 ,每日 1次。连续 7d后 ,心脏采血 ,测TNF α含量 ,处死后摘取胆囊组织 2 0 0mg ,匀浆 ,测TNF α含量 ,并做胆囊病检。结果 :模型组血浆及胆囊局部TNF α均明显高于空白对照组 (P <0 .0 1) ;清肝利湿汤组血浆及胆囊局部TNF α均显著低于模型组 (P均 <0 .0 1) ,且降低局部TNF α的作用优于龙胆泻肝汤组 (P <0 .0 5 ) ;清肝利湿汤组、龙胆泻肝汤组及模型组胆囊病理损害程度有明显轻、中、重差别。结论 :清肝利湿汤具有良好的抗炎作用 ,且疗效优于龙胆泻肝汤 ;血浆TNF α的变化与胆囊局部TNF α的变化基本一致。Objective: To study the effect of QGLS on Tumor Necrosis Factor α(TNF α)in serum and the gallbladder tissue. Methods:The 40 rabbits were divided randomly into four groups:the normal control group, the model group and two groups treated by QGLS decoction and Long Dan Xie Gan(LDXG)decoction respectively. Except the normal group, the others were operated. The LDXG and QGLS decoction treating groups were filled drugs through gastric tube once a day, as well as the normal controls and the model group were filled water. After 7 days, got the blood samples and killed the rabbits to examine the gallbladders pathologically. Measured TNF α in serum and 200 mg gallbladder tissue. Results:the TNF α of QGLS group in serum and gallbladder were significantly lower than them of model group ( P<0.01), and the TNF α of gallbladder tissue in QGLS group was significantly lower than that in LDXG group ( P< 0.05 ). The pathological injures of gallbladder in QGLS group was lightest. Conclusion:QGLS decoction had better anti inflammatory effect than LDXG decoction and the change of TNF α in serum was alike that in gallbladder tissue.

关 键 词：胆囊炎 肿瘤坏死因子 清肝利湿汤 胆结石 

分 类 号：R259.756[医药卫生—中西医结合]