硬膜外腔注射咪唑安定的镇静作用研究  

作　　者：刘子贵[1] 赵静[1] 

机构地区：[1]浙江省丽水市人民医院,323000

出　　处：《浙江临床医学》2001年第9期641-642,共2页Zhejiang Clinical Medical Journal

摘　　要：目的 研究硬膜外腔注射咪唑安定的镇静作用。方法 下腹部以下的手术病人 ,硬膜外腔注射不同剂量咪唑安定 (D) ,随机分成四组 :Ⅰ组0.05mg/kg;Ⅱ组0.10mg/kg ;Ⅲ组0.15mg/kg ;Ⅳ组0.20mg/kg,观察用药前后不同时刻的血压、心率、呼吸次数、氧饱和度、镇静程度的变化 (S)及舌后坠的发生情况。结果 各组用药前后的血压、心率稳定 (p>0.05) ;各组间起效时间和入睡时间无显著性差异 (p>0.05) ,分别为 (3.219±0.393)min和 (6.906±1.007)min;镇静程度的变化与用药剂量呈直线相关 ,方程为S=0.04 +20.25D ,r=0.9815 ,即剂量每增加0.05mg/kg,镇静程度约增加1级。随镇静程度加深 ,特别在5、6级 ,舌后坠发生率明显增高 ,因此引起SpO2≤95 %发生率增加。结论 硬膜外腔注射咪唑安定镇静 ,是硬膜外麻醉中的可选途径 ,具有预见性好 ,操作简便的特点 ,但应注意舌后坠的发生。Objective To study the sedative effect of epidural imidazolum injection during lower abdominal operation. Methods According to different doses of epidural imidazolum injection, patients were divided into four groups: Group Ⅰ(n=8) 0.05mg/kg; Group Ⅱ(n=8) 0.1mg/kg; Group Ⅲ(n=7) 0.15mg/kg; Group Ⅳ(n=6) 0.2mg/kg. Results There were no significant differences in action time (3.219±0.393min) and time to fall asleep (6.906±1.007min) between different groups. There was linear correlation between the change of sedation (S) and the doses of imidazolum injected (D). The regression equation was S=0.04±20.25D, r=0.9815. The incidence of airway obstruction caused by the tongue increased with the sedation degree. Conclusion Epidural imidazolum injection was a possible method of epidural anesthesia with good prejudgment, but the incidence of airway obstruction caused by the tongue must be noted.

关 键 词：硬膜外腔 咪唑安定 麻醉术 硬膜外麻醉 

分 类 号：R614.42[医药卫生—麻醉学]