抗癌新药氟哌酸基甲硫酰(2-乙酰基苯)腙的伏安法研究  

Voltammetric Behavior of New Anticancer Drug Norfloxacinylcarbothioic-(2-acetylbenzyl)hydrazone

作　　者：刘盛辉[1] 李昌新[1] 莫卫民[1] 黄荣斌[1] 孙楠[1] 孙长林[1] 

机构地区：[1]浙江工业大学化学工程学院,杭州310014

出　　处：《分析化学》2001年第12期1370-1377,共8页Chinese Journal of Analytical Chemistry

基　　金：浙江工业大学工程科学研究中心 (No .gc19980 3 );浙江省分析测试基金 (No .0 10 3 5 )资助项目

摘　　要：氟哌酸基甲硫酰 (2 乙酰基苯 )腙 (norfloxacinylcarbothioic (2 acetylbenzyl)hydrazone ,简称NCABH)是在缩胺硫脲的结构中引入氟哌酸基合成的一种新抗癌药物。本文采用线性扫描伏安法、循环伏安法和常规脉冲溶出伏安法研究了该药物的电化学行为。实验结果表明 :NCABH在电极表面存在吸附特性 ,在pH =10的 0 .2mol LNa2 B4 O7 NaOH缓冲溶液中 ,该药物在 - 0 .72V(vs .SCE)处有一灵敏的还原峰 ,在选定的最佳条件下 ,浓度在 2 .0× 10 - 7～ 4 .0× 10 - 5mol L与其峰电流有良好的线性关系 ,检测限为 5 .0× 10 - 8mol L ,方法用于模拟尿、血清样品中痕量药物的测定 ,回收率均在 95 %～ 10 2The voltammetric behavior of new anticancer drug norfloxacinylcarbothioic-(2-acetylbenzyl) hydrazone (NCABH) has been studied by means of linear potential sweep voltammetry, cyclic voltammetry, normal pulse stripping voltammetry. In the medium of Na2B4O7-NaOH (pH = 10), a sensitive peak is observed at -0.72 V(vs. SCE). The peak current is proportional to the concentration of NCABH in the range of 2.0 x 10(-7) similar to 4.0 x 10(-5) mol/L and the detection limit is 5.0 x 10(-8) mol/L. The method has been applied to the determination of trace NCABH in mimic samples of human urine and blood serum without pretreatment. The recovery was 95% similar to 102%.

关 键 词：氟哌酸基甲硫酰(2-乙酰基苯)腙 伏安法 药物分析 抗癌药物 电化学行为 

分 类 号：O657.1[理学—分析化学]