喹诺酮类药物的示波测定  

Oscillographic Determination of Quinolone Antibiotics

作　　者：胡娟[1] 闻京伟 

机构地区：[1]平顶山师范高等专科学校化学系,平顶山467002 [2]河南省药品检验所

出　　处：《应用化学》2001年第12期1009-1011,共3页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金 ( 2 9775 0 18);河南省教育厅自然科学基础研究项目 ( 2 0 0 0 5 30 11)资助课题

摘　　要：喹诺酮类药物属于人工合成抗生素,至今已开发或正在开发的约50多种,成为抗感染药物中最活跃的研究领域之一,是一类有巨大潜力的新型抗菌药.Five quinolone antibiotics were determined by oscillographic chronopotentiometry, using a buffer solution of 0 20 mol/L KH 2PO 4-NaOH(pH=6 8). The sensitivity incisions for enoxacin(ENX), ciprofloxacin(CPLX), ofloxacin(OFLX), fleroxacin(FLRX) and sparfloxacin(SPLX) in result of redox reaction on the hang-Hg electrode were observed on the oscillograms at -1 31 V ?-1 44 V? -1 36 V? -1 28 V? -1 62 V, respectively. The incision heights were linearly proportional to the drug concentration respectively in the range of 7 35~64 2, 16 0~80 7, 4 00~36 7, 12 6~200 0, 9 8~83 4 mg/L with relative standard deviations of 0 7%~1 6%. The experiment results showed that quinolone antibiotics exhibited electrochemical activity. The method has advantages of simplicity, convenience and avoiding from interferences.

关 键 词：喹诺酮类药物 测定 示波计时电位法 抗生素 药物分析 

分 类 号：R978.1[医药卫生—药品] R917[医药卫生—药学]