乙肝Ⅱ号对小鼠免疫性慢性肝损伤的抗自由基损伤作用  

Antioxidation of Prescription №. II for Anti-hepatitis B in Experimental Mice with Chronic Immuno-Hepatic Injury

作　　者：钱涯邻[1] 孙沛毅[2] 孙云[2] 

机构地区：[1]江苏省苏北人民医院,扬州225001 [2]扬州大学医药研究中心

出　　处：《中国中医药信息杂志》2001年第10期23-24,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：江苏省科委指导性课题(BS96355)

摘　　要：目的:研究乙肝Ⅱ号对免疫性肝损伤小鼠抗自由基的作用及其机理。方法:取异种动物的肝提取物作为抗原免疫纯系小鼠产生抗肝抗体,形成慢性实验性免疫性肝损伤,观察小鼠血清丙二醛(MDA)含量,超氧化物歧化酶(SOD)及谷胱甘肽过氧化物酶(GSH-PX)活力的变化以及乙肝Ⅱ号对MDA、SOD和GSH-PX变化的影响。结果:乙肝Ⅱ号组与模型组相比,小鼠血清MDA含量下降,SOD活力上升,GSH-PX活力上升,变化的程度与用药量呈量效关系,且抗自由基作用优于阳性对照乙肝宁颗粒剂组。结论:乙肝Ⅱ号对免疫性肝损伤小鼠具有抗自由基损伤的作用。Objective:Prescription №.Ⅱ for antihepatitis B(PⅡAHB),was studied for its antioxidation in immono-hepatic injury. Method:The chronic hepatic injury was induced by injection with antigen from liver extraction of heterogenous animal. The blood samples were taken and measured for the level of malonyldialdehyde(MDA), and for the change of superoxide dismutase(SOD) in blood and glutathione peroxidase(GSH-PX) in blood. Result:Compared with control animals, PⅡAHB showed some inhibitory effect on changes of SOD,MDA and GSH-PX. Therefore the hepatic injury was alleviated. Conclusion:It is suggested that the therapeutical action of PⅡAHB on hepatitis B be associated with its antioxidation .

关 键 词：免疫性肝损伤 乙肝Ⅱ号 谷胱甘肽过氧化物酶 丙二醛 超氧化物歧化酶 中药 药理 

分 类 号：R285.5[医药卫生—中药学]