免疫算法用于多组分二维色谱数据的解析  

An Application of Immune Algorithm to the Resolution of Multicomponent Overlapping Two-way Chromatogram

作　　者：邵学广[1] 孙莉[1] 

机构地区：[1]中国科学技术大学化学系,合肥230026

出　　处：《分析化学》2001年第7期768-770,共3页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金资助项目 (No .2 9975 0 2 7)

摘　　要：通过对免疫系统抗体对抗原消除作用及其记忆功能的模拟 ,提出了解析二维数据矩阵的新方法。采用模拟的EMG公式作为抗体输入 ,对二维信号逐行进行迭代消除 ,从重叠峰中提取单一组分的色谱信息和光谱信息。通过对二维色谱数据的解析 ,结果表明 ,该方法可方便地用于多组分重叠二维色谱的解析。A novel immune algorithm for the resolution of two-way overlapping analytical signals was proposed by imitating the defending and memory mechanisms of natural immune system. The method took the simulating chromatograms as antibodies, and eliminated the data matrix iteratively row by row until the residual did not change. After the iteration was over, the chromatograms and absorption spectra of each component could be obtained at the same time. A two-way experimental high performance liquid chromatographic data matrix was investigated in this paper, and it was proven by the result that the method was a convenient tool for resolution of two-way overlapping analytical signals.

关 键 词：免疫算法 数据解析 重叠二维色谱 重叠峰 

分 类 号：O657.7[理学—分析化学] O242.23[理学—化学]