高效液相色谱核磁共振仪联用技术在耐哌地尔杂质检测中的应用  

Application of High Performance Liquid Chromatography Coupled with Nuclear Magnetic Resonance Spectroscopy for the Identification of Impurity in Naftopidil

作　　者：杨春[1] 司伊康[1] 贺文义[1] 

机构地区：[1]中国医学科学院,中国协和医科大学药物研究所,北京100050

出　　处：《分析化学》2001年第7期796-798,共3页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金资助项目 (No .39870 86 3)

摘　　要：用高效液相色谱 核磁共振 (HPLC CNM)联用技术中的连续流动和停止流动两种模式对萘哌地尔中杂质进行检测 ,根据1HNMR ,1H 1HCOSY谱完成了主要杂质 1 萘环 丙三醇结构鉴定。HPLC NMR是解决合成药物中杂质结构确证的简便。Using stopped-flow and on-flow high performance liquid chromatography-nuclear magnetic resonance spectroscopy (HPLC-NMR) to detecting the final synthetic drug of naftopidil, the structure and the percentage of the impurity in naftopidil was determined by (HNMR)-H-1 and H-1-H-1 COSY spectra. The main impurity, 1-naphthylglycerol, was detected. HPLC-NMR is a simple and convenient method for the identification of the impurity structure in the synthetic drug.

关 键 词：高效液相色谱 核磁共振 萘哌地尔 药物分析 抗高血压药物 杂质检测 

分 类 号：TQ460.7[化学工程—制药化工]