细胞周期分子机制的成功探索——2001年诺贝尔生理及医学奖部分工作介绍  

Successful Exploration of the Molecular Mechanism of Cell Cycle

作　　者：兰蕾[1] 赫荣乔[1] 

机构地区：[1]中国科学院生物物理研究所,脑与认知科学研究中心,中国科学院视觉信息加工重点实验室,北京100101

出　　处：《生物化学与生物物理进展》2001年第6期773-777,共5页Progress In Biochemistry and Biophysics

摘　　要：细胞周期是指连续分裂的细胞从一次有丝分裂结束到下一次有丝分裂完成所经历的整个序贯过程 .在这一过程中 ,细胞的遗传物质 (DNA)经过复制平均分配到两个子细胞中 .细胞周期中每一事件都是有规律、精确地发生 ,并且在时间与空间上受到严格调控 .细胞周期中最关键的三类调控因子是 :cdc基因、周期蛋白依赖性激酶 (CDKs)及细胞周期蛋白 (cyclin) .The cell cycle is a successive process between two mitosis divisions. During these courses, the cellular genetic materials, for instance DNA, are equally assigned to two daughter cells after replication. Each cell is endowed with its own share of the parental chromosomes. The schedule of events in cell cycle happens in the presence of regularity, precision and perfect temporal and spatial restriction. CDKs, cyclins and cdc are essentially key regulators of three families in control of cell cycle. The discovery of these regulators has important values on both basic research and applied biotechnology.

关 键 词：细胞周期 cdc基因 周期蛋白依赖性激酶 细胞周期蛋白 分子机制 诺贝尔生理学奖 诺贝尔医学奖 

分 类 号：Q253[生物学—细胞生物学] Q26