乙丙型和乙戊型肝炎病毒双重感染的危险因素  

A study of risk factors for HBV and HCV, HBV and HEV dual infections

作　　者：张冠群[1] 李艳[1] 杨翌[1] 汪保国[1] 陈思东[1] 

机构地区：[1]广东药学院热带病研究室,广东广州510224

出　　处：《疾病控制杂志》2001年第4期300-302,共3页Chinese Journal of Disease Control and Prevention

基　　金：广东省高教厅自然科学基金资助课题 ;编号为粤高教科 [1996 ]32号

摘　　要：目的　了解乙型病毒性肝炎 (Hepatitis B)患者重叠感染丙型肝炎病毒 (HCV)或戊型肝炎病毒 (HEV)的危险因素。方法　对 5 5例 HBV和 HCV双重感染及 5 1例 HBV和 HEV双重感染病例 ,以 1∶ 1配对方式选取对照 ,用酶联免疫吸附测定法 (EL ISA)和聚合酶链反应 (PCR)法检测各型肝炎病毒感染指标 ,配对χ2 分析和多因素条件 logistic回归分析法确定危险因素。结果　单因素分析发现 :输液史、牙科手术史、输血史、家庭外肝炎接触史、外餐习惯等因素与乙丙型肝炎病毒双重感染有关 ,其 OR值分别为 5 .6 7、2 3.0、41.0、8.0、3.0。logistic多因素逐步回归分析 ,输血史为乙丙型肝炎病毒双重感染的独立危险因素。家庭成员肝炎史和家庭外肝炎接触史与乙戊型肝炎病毒双重感染有相关性 ,其 OR值分别为 35 .0和 12 .0。家庭成员乙型肝炎史为乙戊型肝炎病毒双重感染的危险因素。结论　输血史为乙丙型肝炎病毒双重感染的危险因素 ,家庭成员乙型肝炎史为乙戊型肝炎病毒双重感染的危险因素。Objective To investigate the risk factors for HCV、HEV superinfection in patients with hepatitis B. Methods 55 cases of dual infections of HBV and HCV, 51 cases of dual infections of HBV and HEV were matched by 1∶1 individual matching. Serum markers hepatitis A^G viruses were tested among patients by PCR and ELISA. Risk factors were assessed by univariate match χ 2 analysis and conditional multivariate logistic regression analysis. Results Univariate analysis showed that there were relations between transfusion, teeth operation, blood transfusion, hepatitis contact out of family, out eating habit and the dual infections of HBV and HCV. Their odds ratio(OR) were 5.67, 23.0, 41.0, 8.0 and 3, respectively. Conditional multivariate logistic regression analysis showed that the history of blood transfusion was risk factor for the dual infections of HBV and HCV. Univariate analysis showed that there were relations between the history of hepatitis in family members, hepatitis contact out of family members and the dual infections of HBV and HEV. The odds ratio(OR) were 35 and 12, respectively. Conditional multivariate logistic regression analysis showed that the history of hepatitis in family members was risk factor for dual infections of HBV and HEV. Conclusions The history of blood transfusion is risk factor for dual infections of HBV and HCV. The history of hepatitis in family members is risk factor for dual infections of HBV and HEV.

关 键 词：肝炎 并发症 重叠感染 流行病学 传染病 酶联免疫吸附法 

分 类 号：R512.6[医药卫生—内科学] R373.21[医药卫生—临床医学]