糖尿病血小板聚集功能和血浆纤维蛋白原的测定  

MEASUREMENT OF PLATELET AGGREGATION AND PLASMA FIBRINOGEN IN DIABETES MILLITUS

作　　者：孟凡军[1] 张茂宏[2] 

机构地区：[1]青岛医学院内科学教研室 [2]山东医科大学

出　　处：《青岛医学院学报》1991年第3期230-233,共4页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：应用肾上腺素(EPN)、二磷酸腺苷(ADP)和胶原(COLL)三种致聚剂,对52例糖尿病(DM)患者的血小板聚集功能进行测定,同时测定了血浆纤维蛋白原(Fg)浓度,并按有无血管并发症进行分组比较,并对血小板聚集功能与Fg,空腹血糖(FPG)、胆固醇(CH)和甘油三酯(TG)的关系进行了观察。结果表明,ADP诱导的各组血小板聚集功能(PAgT)均明显升高(P<0.001～0.05),有血管并发症组较无血管并发症组显著升高(P<0.05);但对EPN和COLL诱导的PAgT无显著性差异。血浆Fg浓度显著高于对照组(P<0.001),在无血管并发症的早期即显著高于对照组(P<0.001)。ADP-PAgT与FPG,CH和TG无相关关系,但与Fg浓度则呈明显的正相关(r=0.565,P<0.002)。提示PAgT和Fg与血管病变密切相关,可能为其发病因素之一。Platelet aggregation induced by Epinephrine (EPN), adenosine diphosphate (ADP) and collagen (COLL) in 52 patients with diabetes was studied. The concentration of plasma fibrinogen (Fg) was measured at the same time. The relationship between ADP-induced platelet aggregative test (ADP-PAgT)and Fg, fasting plasma glucose (FPG), cholesterol (CH) and triglyceride (TG) was also observed. The patients fell into two groups: one with vascular complications and the other without vascular complications. The results showed that ADP-PAgT was significantly higher in both of the patient groups than in the controls, and higher in the group with vascular diseases than in the group without vascular diseases. No significant difference was found in EPN-or COLL-induced PAgT. The concentration of plasma Fg in patients with diabetes mellitus was higher than that in the controls. There was no correlation between FPG, CH, TG and ADP-PAgF, but there was a positive correlation between ADP-PAgT and Fg. (γ=0.565, P<0.002). The results indicated that the close relation between PAgT and Fg may be one of the causes of vascular diseases in diabetes.

关 键 词：血小板 糖尿病 血管疾病 

分 类 号：R587.1[医药卫生—内分泌]