先天性心脏病合并肺动脉高压患者体外循环围术期血浆内皮素水平的动态观察  

Perioperative observation of plasma endothelin in patients with congenital heart disease with pulmonary hypertension underwent open heart surgery

作　　者：宋逢林[1] 罗会昭[1] 刘峰[1] 喻杰锋[1] 李炎升[1] 

机构地区：[1]中南大学湘雅二医院胸心外科,长沙410011

出　　处：《湖南医科大学学报》2001年第4期379-380,共2页Bulletin of Hunan Medical University

摘　　要：应用放射免疫方法 ,对 2 2例左向右分流型先天性心脏病合并肺动脉高压患者 (肺高压组 )及 16例左向右分流先天性心脏病无肺高压患者 (无肺高压组 )体外循环心内直视手术围术期血浆内皮素水平进行了动态检测。结果发现 :两者体外循环心内手术围术期血浆内皮素水平显著升高 ;无肺高压组术后血浆内皮素水平迅速下降并于手术后 6h恢复至术前水平 ;肺高压组术后血浆内皮素水平下降缓慢 ,术后To elucidate the correlation between endothelin(ET) and pulmonary hypertension, plasma ET was measured perioperatively by radioimmunassay in 22 patients with pulmonary hypertensiom who underwent open heart surgery(PH group)in comparison with 16 patients without pulmonary hypertension(non PH group)also underwent cardiopulmonary bypass(CPB) surgery. Results: Plasma ET was significantly increased during CPB in both group, Plasma ET decreased rapisly and returned to preoperative level within 6 hours after operation in the non PH group. In the PH group, however, plasma ET decreased slowly and did not return to preoperative level within 48 hours postoperation.

关 键 词：先天性心脏缺损 肺动脉高压 内皮素 心肺转流术 并发症 体外循环 

分 类 号：R541.1[医药卫生—心血管疾病]