甲状腺功能状态对异喹胍药物代谢的影响  

Effect of thyroid function on the metabolism of debrisoquine

作　　者：但汉雄[1] 刘翠霞[1] 江南[1] 徐来[2] 

机构地区：[1]湖北药检高等专科学校,湖北武汉430064 [2]江汉大学武汉市卫校,湖北武汉430030

出　　处：《中国医院药学杂志》2001年第10期594-595,共2页Chinese Journal of Hospital Pharmacy

摘　　要：目的：测定不同甲状腺功能状态时大鼠24 h尿样中异喹胍（DB）和其体内主要代谢产物4-羟异喹 胍（4-OH-DB）的含量及其代谢比值（MR）。方法：采用气相色谱技术。结果：对照组、甲亢组和甲低组大鼠灌胃DB 0.5 mg·kg-1，求得其MR比值分别为： 0. 164±0.04，0.084±0.011和0.323±0.046(P＜0.01) ； 其24 h尿中DB含量（μmol·l-1）分别为：64.8±5.5，48.4±3.0 和100.2±12.9(P＜0.01) ；24 h尿中4-OH-DB含量（μmol·l-1）分 别为：416.7±86.6，574.3±72.0（P＜0.01)和314.6±39.6（P ＜0.05)结论：甲状腺功能提高时大鼠对异喹胍的代谢能力明显增加，消除加速；甲状腺功能降低则相反。OBJECTIVE To determine the concentration of debrisoquine (DB)and its essential metabolite 4-hydroxy debrisoquine (4-OHDB) in rat's 24-hours urine on the different thyr oid functional state,and the ratio between debrisoquine and 4-hydroxy debrisoqu ine (metabolic ratio，MR)in urine. METHODS Gas chromatography was used with flame ionization detector(GC-FID). RESULTS The metabolic ratio (MR)of debrisoquine following ip 0.5 mg·kg-1 in c ontrol, hyperthyroidism and hypothyroidism group rats were：0.164±0.04，0 .084±0.011,0.323±0.046(P＜0.01)respectively；The concentration o f debrisoquine in 24-hours urine were (μmol·l-1):64.8±5.5，48.4 ±3.0(P＜0.01),100.2±12.90 (P＜0.01) ；The concentration 7 of 4-hydrovy debrisoquine in 24-hours urine were (μmol·l-1):416.6± 86.6，574.3±72.0（P＜0.01,314.6±39.6（P＜0.05. CONCLUSIONS Debrisoquine hydroxylation increased on the hyperthyroidism rats.

关 键 词：甲状腺 异喹胍 4羟异喹胍 药物代谢 气相色谱法 

分 类 号：R977.14[医药卫生—药品] R969.1[医药卫生—药学]