佛司可林两个类似物对饮水导致的人眼压升高的影响(英文)  

Effects of two forskolin analogs on the elevation of ocular pressure in human

作　　者：杨为民[1] 李新华[1] 陈植和[1] 聂玲辉 李玲[1] 雷伟亚[1] 

机构地区：[1]昆明医学院天然药物药理重点实验室,昆明650031

出　　处：《眼科研究》2001年第6期556-559,共4页Chinese Ophthalmic Research

基　　金：云南省自然科学基金资助 (基金编号 :95C0 70M )

摘　　要：目的　实验观察佛司可林两个类似物 ,即isoforskolin (isoF) ,deacetylforskolin (deaF) ,对饮水导致急性人眼压升高的影响。　方法　按随机双盲法设计 ,将佛司可林两个类似物配成的滴眼液分别滴入 1眼 ,相应的溶媒滴入另眼。让受试者饮水 ( 14ml/kg)造成急性人眼压升高。给药前后用气动式眼压计测定眼压值 ,观察眼压变化。　结果　表明isoF( 0 5 % )及deaF( 1 0 % )均有抑制作用 ,最大抑制率分别为 11 4%及 12 0 % ,并且副作用小。　结论　实验证明isoF( 0 5 % )及deaF( 1 0 % )ObjectiveTo investigate the effects of two compounds,isoforskolin (isoF) and deacetylforskolin (deaF) on the acute increase of intra ocular pressure (IOP) induced by water drinking (14 ml/kg) in healthy subjects when topically administered.MethodsThe study was carried out in double blind and randomized healthy subjects.Drops of the two drugs were instilled into one eye while the corresponding vehicle was administrated into the contralateral eye.IOP was measured with pneumatonometer before and after administration respectively.ResultsThe results showed both isoF (0 5%) and deaF (1 0%) decreased the acute elevation of IOP induced by water drinking with the maximal inhibitory rates of 11 4 and 12 0% respectively.The drugs were well tolerated by subjects.Conclusion IsoF and deaF are effective on inhibition of the IOP increase.

关 键 词：眼压升高 饮水 佛司可林类似物 isoF DEAF 

分 类 号：R965[医药卫生—药理学] R988.1[医药卫生—药学]