甲减患者总同型半胱氨酸水平及其相关因素分析  

The Change of Total Homocysteine Levels in Hypothyroidism

作　　者：郗光霞[1] 雷昆[2] 

机构地区：[1]山西医科大学第二医院内分泌科,030001 [2]山西省人民医院,030012

出　　处：《中国误诊学杂志》2001年第9期1296-1298,共3页Chinese Journal of Misdiagnostics

摘　　要：目的　探讨甲减患者血浆总同型半胱氨酸 (t Hcy)的变化及其与叶酸、维生素 B1 2 、血清胆固醇的相关关系。方法　应用荧光偏振免疫发光技术测定 45例甲减患者及 48例正常对照者 t Hcy、叶酸、维生素 B1 2 水平 ,应用生化技术测定血清总胆固醇 ;同一参数在甲减组与对照组间进行 t检验 ,t Hcy与各参数间的关系采用 Spearman等级相关。结果　甲减组 t Hcy及血清胆固醇显著高于对照组 ;甲减组叶酸及维生素 B1 2 显著代于对照组 ,甲减患者 t Hcy与叶酸、维生素 B1 2分别呈显著负相关 ,与胆固醇呈正相关 ,但无统计学意义。结论　甲减患者 t Hcy和胆固醇升高可加速其动脉硬化的发生及发展 ,加速冠心病的进程 ,补充叶酸及维生素 B1 2 治疗有望在一定程度上降低 t Hcy的水平 。Objective To investigate the changes of serum tHcy, and the relationship between tHcy and folacin, cobalamin as well as cholesterol.Methods 45 patients with hypothyroidism and 48 control subjects were recruited to the study. The tHcy, folacin,cobalamin were measured using FPLIA technology. Serum cholesterol was detected with biochemical methods.The relationship between tHcy and the other parameters were presented as Spearman rank correlations.Results Plasma tHcy and serum cholesterol were higher in patients with hypothyroidism than in control subjects. Serum folacin and cobalamin were lower in patients group than in control group.The tHcy was negatively correlated with cobalamin and folacin.Conclusions The increase of tHcy and cholesterol observed in hypothyroidism patients may contribute to high cardiovascular risk.Supplementing cobalamin and folacin may decrease plasma tHcy level in hypothyroidism.

关 键 词：同型半胱氨酸 甲状腺功能减退 叶酸 维生素B12 胆固醇 

分 类 号：R581.2[医药卫生—内分泌]