肝素钙在早期慢性肾功能不全患者中的应用  

The application of heparin calcium in chronic renal insufficiency

作　　者：左巍[1] 左伟[2] 陈红[1] 关欣[1] 赵红[1] 何丽萍[1] 

机构地区：[1]沈阳军区总医院肾内科,辽宁沈阳110016 [2]沈阳军区总医院检验科,辽宁沈阳110016

出　　处：《中国生化药物杂志》2001年第5期252-254,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的观察肝素钙对慢性肾功能不全 (CRI)的治疗作用及不良反应。方法应用肝素钙治疗 3 4例早期CRI患者并对其肾功能、脂质代谢、凝血指标及 2 4h尿蛋白排出量进行了治疗前后的观察。结果观察组治疗后与治疗前相比血肌酐、尿素、尿蛋白明显下降 ,内生肌酐清除率明显升高 ;观察组治疗前纤维蛋白原、总胆固醇 (Tch)、甘油三酯 (TG)、低密度脂蛋白 (LDL)较对照组明显增高 ;活化部分凝血活酶时间 (APTT)、高密度脂蛋白 (HDL)、载脂蛋白A(ApoA)、ApoA ApoB较对照组明显降低 ;治疗前后相比APTT、HDL、ApoA、ApoA ApoB明显升高 ,纤维蛋白原、Tch、TG、LDL明显下降 ;无明显副作用。结论肝素钙具有降低尿蛋白、纠正脂质代谢紊乱、改善血液黏度的作用 。PurposeThe aim is to study role and side effects of heparin calcium on the patients with chronic renal insuffciency(CRI).Methods34 cases of the patients with CRI were treated by heparin calcium and renal function,lipid metabolism,items of blood coagulation,and urine protein output every 24 hours of the patients were observed before and after treatment.ResultsSerum creatinine,blood urea and urine protein decreased significantly meanwhile endogenous creatinine clearance rate increased significantly.In the pre treatment patients with CRI,fibrinogen,total cholesterol(Tch),triglyceride(TG)low density lipoprotein(LDL) increased signifcantly,activated partial thromboplastin time(APTT),high density Lipoprotein(HDL),apolipoprotein A(ApoA),and ApoA/ApoB decreased signifcantly.APTT,HDL,ApoA,and ApoA/ApoB increased signifrcantly meanwhile frbrinogen,Tch,and TG,LDL decreased signifcantly.There is no significantly side effect.ConclusionHeparin calcium can reduce urine protein and lipidemia,which is safe and reliable in the treatment of CRI.

关 键 词：肝素钙 慢性肾功能不全 脂质代谢 凝血指标 肾功能 治疗 

分 类 号：R692.505[医药卫生—泌尿科学] R977[医药卫生—外科学]