丙型肝炎患者抗-NS5抗体与α-干扰素疗效关系的研究  

Study on the Relationship between the Anti-NS5 Antibody and the Efficacy of Interferon Alpha of Patients with Hepatitis C

作　　者：苗祥宇 孙南雄[2] 张永祥[2] 边维良[2] 王家猛 

机构地区：[1]宿迁市人民医院内科,江苏宿迁223800 [2]南京医科大学一附院肝炎研究所,江苏南京210029

出　　处：《镇江医学院学报》2001年第4期441-443,共3页Journal of Zhenjiang Medical College

基　　金：南京医科大学校青年基金 (NY2 0 0 0 1 5 )

摘　　要：目的 :探讨丙型肝炎患者IgG抗 NS5抗体与α 干扰素疗效的关系。方法 :以重组HCV抗原及NS3、NS5区段多肽作为抗原 ,以ELISA法检测丙型肝炎患者α 干扰素治疗前血清IgG抗 NS3、抗 NS5、抗 HCV抗体及其滴度。结果 :α 干扰素治疗有效组的抗 NS5抗体的阳性率为 80 % ( 8 1 0 ) ,无效组为 2 0 % ( 2 1 0 ) ,两组比较有显著差异 (P <0 .0 5) ;有效组抗 NS5抗体滴度显著性高于无效组 (P <0 .0 5) ;有效组和无效组抗 NS3、抗 HCV抗体阳性率及抗体的滴度无明显差异 (P >O .0 5)。结论 :治疗前血清IgG抗 NS5抗体可以作为α 干扰素疗效的一个预测指标。Objective:To evaluate the relationship between IgG anti NS5 antibody and the efficacy of interferon alpha in patients with hepatitis C.Method: The recombinated HCV antigen and NS3,NS5 sector polypeptide were used as antigen,the distributions of positive ratio and dilution of IgG anti NS5, anti NS3 and anti HCV antibodies of serum of 20 patiens before the treatment of interferon alpha were detected by enzyme linked immunoadsordent assay(ELISA). Result:The positive ratio of anti NS5 antibody of the patients(8/10,80%)with sustained reactivity were significantly higher than the patients(2/10,20 %)with no reactivity ( P <0.05). The patients with sustained reactivity have significantly higher dilution of IgG anti NS5 antibody than the patients with no reactivity. But there are not significantly discrepancy between the two groups of the positive ratio and the dilution.Conclusion: The level of pretreatment of serum IgG anti NS5 antibody could be used as a predictor of interferon alpha efficacy.

关 键 词：抗-NS5抗体 Α-干扰素 丙型肝炎 疗效 

分 类 号：R512.630.5[医药卫生—内科学]