血浆纤维蛋白原对不稳定型心绞痛危险分层的价值  

The value of plasma plasma fibrinogen in risk stratification of unstable angina

作　　者：薛书峰[1] 赵建华[1] 金军[1] 杨晓明[1] 田利平[1] 

机构地区：[1]洛阳市中心医院心内科,河南洛阳471009

出　　处：《临床心血管病杂志》2002年第1期8-9,共2页Journal of Clinical Cardiology

摘　　要：目的 :探讨血浆纤维蛋白原 (Fib)水平对不稳定型心绞痛 (UA)危险分层的临床价值。方法 :测定10 9例UA患者血浆Fib并与 35例稳定型心绞痛 (SA)患者相对照 ,据血浆Fib >4 .0 0 g/L和Fib <4 .0 0 g/L将UA患者分为Fib升高组 (5 8例 )和Fib正常组 (5 1例 ) ,观察住院期间心血管事件 (包括顽固性心绞痛、急性心肌梗死和心源性死亡 )发生率。结果 :10 9例UA患者血浆Fib较SA患者明显升高 [(4.89± 1.6 2 )∶ (3.85± 0 .74 )g/L ,P <0 .0 1],UA患者中血浆Fib升高组心血管事件发生率明显高于Fib正常组 (41.4 %∶ 5 .9% ,P <0 .0 1)。结论 :血浆Fib水平能预测UA患者住院期间心血管事件 。Objective:To evaluate the value of plasma fibrinogen (Fib) in risk stratification of unstable angina (UA). Method: The plasma Fib levels in 109 patients with UA and 35 patients with stable angina were measured. The patients with UA were divided into Fib elevated group (58 cases Fib> 4.00 g/L) and Fib normal group (51 cases Fib< 4.00 g/L). The cardiovascular event including refractory angina, acute myocardial infarction and cardiac death was observed in the two groups during hospitalization. Result:The plasma Fib levels increased in patients with UA compared with those in patients with SA 〔( 4.89 ± 1.62 )g/L vs ( 3.85 ± 0.74 )g/L, P< 0.01 〕.The cardiovascular event increased in Fib elevated group compared with that in Fib normal group ( 41.4 % vs 5.9 % P< 0.01 ). Conclusion:This study suggests that the plasma Fib can predicate the cardiovascular event during hospitalization of the patients with UA, and could be as a marker for risk stratification.

关 键 词：纤维蛋白原 心绞痛 不稳定型 心血管事件 危险分层 

分 类 号：R541.4[医药卫生—心血管疾病]