体外治疗性超声对大鼠血浆颗粒膜蛋白140和血栓素B_2的影响  

Effect of external therapeutic ultrasound on plasma GMP-140,TxB_2 of rats

作　　者：王海清[1] 曹林生[1] 王德平[2] 蒋小燕[3] 孙向东[1] 李运锋[1] 

机构地区：[1]华中科技大学同济医学院心血管病研究所华中科技大学同济医学院附属协和医院心内科,武汉430022 [2]襄樊市中心医院核医学科 [3]华中科技大学同济医学院附属协和医院康复科

出　　处：《临床心血管病杂志》2002年第1期30-31,共2页Journal of Clinical Cardiology

摘　　要：目的 :研究体外治疗性超声 (ETUS)对大鼠血浆颗粒膜蛋白 14 0 (GMP 14 0 )、血栓烷B2 (TxB2 )影响。方法 :4 6只大鼠接受体外超声治疗 ,频率 0 .8MHz ,声强 2 .1W /cm2 ,持续 1h。采用酶联免疫吸附法测定超声治疗前后大鼠血浆GMP 14 0、TxB2 的改变。结果 :超声治疗后ETUS组GMP 14 0 (5 .0 4± 0 .78) μg/L ,TxB2 (85 .84± 5 .5 1)ng/L ,对照组GMP 14 0 (5 .32± 0 .4 8) μg/L ,TxB2 (87.98± 1.4 8)ng/L ,两者比较差异无显著性意义 (P>0 .0 5 )。结论 :ETUS能使溶栓药向血栓内渗透 ,促进血栓溶解 ,此方法属于无创疗法 ,设备简单 ,操作方便。Objective: In order to study the effect and safety of external therapeutic ultrasound (ETUS) on plasma granular membrane protein 140(GMP 140), thromboxane B 2 (TxB 2) of rats, and to provide a clinical basis for assisting thrombolysis by external therapeutic ultrasound. Method:Fourty six rats were treated with ETUS, which was 0.8 MHz, 1.0 W/cm 2 and lasted for one hour. Before and after treatment by ETUS, the GMP 140 and TxB 2 were detected by ELISA. Result:Before and after treatment by ETUS, the levels of GMP 140 and TxB 2 had no significant changes (P> 0.05 ). Conclusion:It indicates that platelet activity may be not influenced by ETUS.

关 键 词：超声疗法 血小板 a-颗粒膜蛋白 血栓烷B2 血栓溶解疗法 

分 类 号：R454.3[医药卫生—治疗学]