透明质酸钠治疗退行性膝骨关节炎的临床观察  

CLINICAL STUDY ON SODIUM HYALURONATE INTRA-ARTICULAR INJECTION IN TREATMENT OF DEGENERATIVE OSTEOARTHRITIS OF KNEE

作　　者：陈游[1] 彭丹[1] 孙材江[1] 王万春[1] 李菊元[1] 张薇[1] 

机构地区：[1]中南大学湘雅第二医院创伤骨科研究室,长沙410011

出　　处：《中国修复重建外科杂志》2002年第1期19-20,共2页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：目的　观察透明质酸钠注射液对退行性膝骨关节炎 (DOA)的治疗作用。方法　 10 0例 116膝DOA患者关节腔内注入透明质酸钠注射液 2 ml和 1%利多卡因注射液 0 .5 m l,每周给药 1次 ,共 3次。观察治疗前、后关节疼痛、肿胀及积液等症状的缓解 ,以及关节活动度、步行能力、上下楼梯、下蹲和跑步等关节功能的改善情况。结果　 96例 10 8膝获得 1～ 6个月随访 ,显效 39例 (占 40 .6 % ) ;有效 32例 (占 33.3% ) ,进步 16例 (占16 .7% ) ,无效 9例 (占 9.4% )。总有效率为 74.0 %。未见明显毒副作用。结论　透明质酸钠注射液关节腔内注射治疗膝 DOA,具有缓解临床症状。Objective To evaluate the clinical effect of sodium hyaluronate (SH) intra articular injection in treatment of degenerative osteoarthritis (DOA) of knees. Methods One hundred patients (116 knees) suffered from DOA were treated by SH injection intra articularly once a week for three times. According to Lysholm scoring, clinical signs such as pain, swelling, excludes, range of movement (ROM), and the ability of walking, going upstairs and downstairs, squatting, running, were assessed before and after treatment. Results Ninety six cases were followed up for 1 to 6 months. There were obvious improvements in the signs and function of knee in 39 patients (40.6%), only some improvements in 48 patients (50.0%), and no obvious improvements in other 9 patients (9.4%). The total effectiveness rate was 74.0%. No toxic or side effect was observed. Conclusion Intra articular injection of SH has a positive effect in relief of clinical symptoms and in improvement of articular function of DOA of knee.

关 键 词：退行性骨关节炎 透明质酸钠 关节腔内注射 治疗 疗效 

分 类 号：R684.3[医药卫生—骨科学]