透明质酸钠预防屈肌腱粘连的临床研究  

THE CLINICAL STUDY OF ADHESION PREVENTION OF SODIUM HYALURONATE IN FLEXOR TENDON SURGERY

作　　者：王韶进[1] 戴国锋[1] 李昕[1] 刘琦[1] 史东平[1] 

机构地区：[1]山东大学齐鲁医院骨科,济南250012

出　　处：《中国修复重建外科杂志》2002年第1期28-30,共3页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：目的　评价透明质酸钠预防术后屈肌腱粘连的临床效果。方法　 1998年～ 1999年对 47例屈肌腱手术者 ,于肌腱损伤修复部鞘内或局部分别注入两种透明质酸钠凝胶制剂。 A组注入透明质酸钠 I号 ,2 0 m g/ 2 ml,17例 ;B组注入透明质酸钠 号 ,2 0 mg/ 2 ml,16例 ;C组除不用透明质酸钠外 ,其它治疗与 A、B组相同 ,14例。于术后 1、2和 3个月测定相关部位的功能、疼痛和肿胀等情况 ,按关节功能和握拳功能评价透明质酸钠预防粘连的效果。结果　 47例经 1～ 3个月随访 ,A组优良率为 6 4.71% ,B组为 6 8.75 % ,C组为 42 .86 % ,A及 B组与 C组比较有统计学意义 (P<0 .0 5 ) ;各组均未见明显毒副作用。结论　两种透明质酸钠凝胶均有明显抑制术后屈肌腱粘连形成的作用 。Objective To evaluate the effects of sodium hyaluronate on adhesion prevention after flexor tendon surgery. Methods In 47 cases with the flexor tendon surgery, two kinds of sodium hyaluronate jelly preparations were injected into the tendon sheath before suture. Preparation I (20mg / 2ml) was for group A (17 patients) and preparation Ⅱ(20mg / 2ml) was for group B (16 patients). The control group (group C, 14 patients) were treated in the same way except injection of sodium hyaluronate. The functions of afflicted fingers including flexibility, pain and swelling were measured immedicately, at the first, second and the third month after operation. Results All 47 patients were followed up 1 to 3 months. 64.71% patients in group A and 68.75% in group B showed significant improvement. There were significant difference compared with group C ( P <0.05). There were no significant adverse reactions were observed in all groups. Conclusion Two sodium hyaluronate preparations have effects in adhesion prevention after flexor tendon surgery with safety and expedience.

关 键 词：屈肌腱粘连 预防 透明质酸钠 肌腱损伤 修复术 

分 类 号：R687.2[医药卫生—骨科学]