持续恒压扩张中囊内压力对药物渗透性的影响  

EFFECT OF THE ENDOEXPANDER PRESSURE OF CONTINUOUS AND CONSTANT PRESSURE EXPANSION ON THE DRUG PERMEABILITY

作　　者：展望[1] 朱飞[2] 邝荔香[3] 陈刚[3] 鲁义东[3] 宁金龙[2] 

机构地区：[1]海南省人民医院整形外科,海口570311 [2]安徽医科大学附属第一院整形外科 [3]安徽医科大学附属第一院药物检测中心

出　　处：《中国修复重建外科杂志》2002年第1期39-41,共3页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：海南省卫生厅科研基金资助项目 (琼卫 2 0 0 0 -5 8)

摘　　要：目的　研究持续恒压扩张中囊内压力对药物渗透性的影响。方法　在扩张囊内注入 0 .2 %甲硝唑后分为常量扩张组和持续恒压扩张组 ,将扩张囊置入生理盐水中 ,分别于 1、 2、 4、 8、 12、 2 4、 48及 72小时取样 ,测定囊外的药物浓度。结果　常量扩张及持续恒压扩张时 ,扩张囊对甲硝唑均有渗透性 ,囊外药物于 48小时达到有效浓度。持续恒压扩张组各个时间点的药物浓度均大于常量扩张组 ,两组比较有统计学意义 (P<0 .0 1)。结论　持续恒压扩张时囊内压力的增大可增加药物的渗透性。在持续恒压扩张过程中 ,使用 0 .2Objective To investigate the effect of the endoexpander pressure of continuous and constant pressure expansion on the drug permeability. Methods The expanders were divided into two groups, the normal expansion and the continuous and constant pressure expansion (4.6 kPa). Each expander was filled with 0.2% Metronidazole, then the expanders were immersed wholly in normal saline and sealed totally. At several intervals over 72 hours, the surrounding saline was sampled and the drug concentration of the sample was measured respectively. Results Both groups were permeable to the Metronidazole and the concentration outside the expander would reach the effective concentration in 48 hours. The drug concentration of the continuous and constant pressure expansion was higher than that of the normal one and there was significant difference between the two groups ( P <0.01). Conclusion The endoexpander pressure in continuous and constant pressure expansion can enhance the drug permeability. In view of this, in the course of continuous and constant pressure expansion, 0.2% Metronidazole can be used to prevent and control the infection.

关 键 词：皮肤扩张囊 药物渗透 甲硝唑 囊内压力 组织缺损 

分 类 号：R62[医药卫生—整形外科]