重组人表皮细胞生长因子在慢性溃疡创面中的应用  

APPLICATION OF RECOMBINANT HUMAN EPIDERMAL GROWTH FACTOR ON CHRONIC ULCER WOUND

作　　者：朱建辛[1] 张耀明[1] 

机构地区：[1]四川省人民医院骨科,成都610071

出　　处：《中国修复重建外科杂志》2002年第1期42-43,共2页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：目的　观察重组人表皮细胞生长因子 (rh EGF)对慢性溃疡创面愈合的影响。方法　 1999年 10月～ 2 0 0 1年 1月在局部清创后随机对 2 6例患者的慢性溃疡创面 (3cm× 3cm～ 5 cm× 8cm )作为治疗组 ,用rh EGF喷雾剂以 40 0 U / 10 cm2 进行局部喷涂 ,无菌敷料覆盖 ;同期随机对另 2 6例慢性溃疡创面 (2 .5 cm×3.0 cm～ 4.0 cm× 6 .5 cm )用 0 .9%生理盐水进行局部湿敷作为对照组 ,观察创面愈合时间、创面局部及全身反应情况。结果　治疗组中创面不适感消失早 ,脓性分泌物少 ,肉芽组织生长快 ,无过度增生现象。溃疡创面愈合时间治疗组较对照组缩短 7～ 10天 ,经统计学处理 ,有显著性差异 (P<0 .0 1)。结论　 rh EGF有明显促进慢性溃疡创面愈合的作用 ,且愈合时间短。Objective To observe the effect of recombinant human epidermal growth factor(rhEGF) on healing of chronic ulcer wound.Methods From January 1999 to January 2001, twenty six patients with chronic wounds were adopted in this study. Among them, there were 17 males and 9 females, aged from 12 to 61 years. The area of the chronic wound varied from 3 cm×3 cm to 5 cm ×8 cm and the disease course was 7 to 16 days. These patients were treated with rhEGF in the way of sprinkling locally(400U/10 cm 2). Another 26 patients with chronic wounds were adopted as the control group and were treated with 0.9% saline in the same way. The healing time of wounds and the local and systemic reactions of patients were observed. Results The healing time of chronic wounds was shorter obviously to about 7 days with rhEGF than that of the control group and there was significant difference between the two groups( P<0.01) . Conclusion rhEGF can obviously promote the healing of chronic ulcer wound.

关 键 词：重组人表皮细胞生长因子 溃疡创面 创面愈合 

分 类 号：R632.1[医药卫生—外科学]