阿司匹林对老年人血尿酸的影响  

The influence of aspirin on the blood uric acid in the elderly

作　　者：马建芳[1] 陈志群[1] 邱凤英[1] 冯福英[1] 曾爱萍[2] 陈宏[1] 

机构地区：[1]解放军第476医院内科,福州350002 [2]解放军第454医院高干科,南京210002

出　　处：《中国综合临床》2002年第1期53-54,共2页Clinical Medicine of China

摘　　要：目的探讨长期服用小剂量肠溶阿司匹林对老年高血压患者血尿酸的影响。方法用随机双盲法将老年轻、中度高血压 10 5例分为阿司匹林治疗组和对照组。治疗组给肠溶阿司匹林 40 mg/ d,加尼莫地平、开搏通降压治疗 :对照组单用尼莫地平 40 mg/ d、开搏通37.5～ 75 mg/ d,不用肠溶阿司匹林 ,持续治疗 1年。记录治疗前及治疗第 6、12月的血压、心率及血尿酸变化。结果阿司匹林治疗组血尿酸较对照组显著升高 [由 ( 0 .43± 0 .0 7) mmol/ L至 ( 0 .5 6± 0 .0 3) mmol/ L ] ,两组间第 6、12月血尿酸差值比较 P<0 .0 1,有显著性差异。两组血压及其余生化指标无显著差异。结论长期小剂量阿司匹林治疗可引起高尿酸血症 。Objective To study the influence of long time small dose of enteric coated aspirin on the blood uric acid in the elderly hypertension patients.Methods 105 cases of elderly patients with mild or moderate hypertension were double blindly randomized into treatment group and control group.The treatment group were given 40 mg/d enteric coated aspirin plus nimodipine and captopril for reducing blood pressure while control group were only given 40 mg/d nimodipine,or 37.5～75 mg/d captopril but no aspirin for a year.Meanwhile,blood pressure,heart rate and uric acid level were recorded before treatment and at 6 and 12 months during treatment.Results Blood uric acid level was increased remarkably in the treatment group as compared with control group [form (0.43±0.07) mmol/l to (0.56±0.03) mmol/L].There was significant difference in uric acid level at 6 and 12 months between the two groups (P< 0.01) .However,blood pressure and other biochemical indexes were not significantly different.Conclusion Long time use of small dose aspirin can result in hyperuricemia so necessary preventive measure should be taken.

关 键 词：阿司匹林 老年人 尿酸 高血压 

分 类 号：R96[医药卫生—药理学]