第二代抗癌药物卡铂与L-硒代蛋氨酸和L-蛋氨酸的相互作用研究  

The Interaction between the Second Generation Anticancer Drug Carboplatin and L-Selenomethionine

作　　者：刘琴[1,2] 林骏[1] 张俊勇[1] 朱龙根[1] 郭子建[1] 

机构地区：[1]南京大学配位化学国家重点实验室 [2]2南京经济学院食工系,南京210003

出　　处：《无机化学学报》2002年第1期37-40,共4页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金资助项目(No.29925102)。

摘　　要：The reactions of carboplatin ([Pt(NH3)2(CBDCA)], in which CBDCA is cyclobutane 1,1, dicarboxylate) with L selenomethionine (L Se MetH) and L methionine (L MetH) were investigated using electrospray mass spectroscopy (ESMS) and 2D HSQC NMR spectroscopy. The dominant products for both reactions are bis chelated complexes [Pt(L Se Met)2] and [Pt(L Met)2]. These results are different from those observed for the reactions of cisplatin ([PtCl2(NH3)]) with L Se MetH or L MetH, in which the main products are mono chelated complexes [PtCl(NH3)(L Se Met)] or [PtCl(NH3)(L Met)]. This work provides insights into the differences between cisplatin and carboplatin in their reactivity and mechanism of reaction.The reactions of carboplatin ( [ Pt (NH3) (2) (CBDCA) 1, in which CBDCA is cyclobutane- 1, 1, -dicarboxylate) with L-selenomethionine ( L-Se-MetH) and L-methionine ( L-MetH) were investigated using electrospray mass spectroscopy (ESMS) and 2D[H-1-N-15] HSQC NMR spectroscopy. The dominant products for both reactions are bis-chelated complexes [ Pt ( L-Se-Met) (2)] and [ Pt ( L-Met)(2)]. These results are different from those observed for the reactions of cisplatin ( [ PtCl2 (NH3)]) with L-Se-MetH or L-MetH, in which the main products are mono-chelated complexes [ PtCl (NH3) ( L-Se-Met) I or [ PtCl (NH3) ( L-Met)]. This work provides insights into the differences between cisplatin and carboplatin in their reactivity and mechanism of reaction.

关 键 词：卡铂 L-硒代蛋氨酸 L-蛋氨酸 电喷雾质谱 抗癌药物 相互作用 药理 

分 类 号：R979.1[医药卫生—药品] R962[医药卫生—药学]