儿童普及接种甲肝疫苗对人群甲肝抗体水平的影响  

The effects on HAV antibody levels of population in children vaccinated against viral hepatitis A

作　　者：庄昉成[1] 姜器[2] 毛子安[1] 钱汶[1] 忻亚娟[1] 杨年忠[2] 於平[2] 李丽[2] 柴少爱[1] 

机构地区：[1]浙江省医学科学院,浙江杭州3100132 [2]浙江省台州市椒江区卫生防疫站

出　　处：《浙江预防医学》2002年第1期1-2,共2页Zhejiang Journal of Preventive Medicine

摘　　要：目的　研究儿童中普及接种甲肝活疫苗后 ,对人群甲肝总抗体水平的影响。方法　选择浙江省台州市椒江城区 ,按不同年龄分成 7组 ,分别于 1991年疫苗接种前及 2 0 0 0年儿童普及接种疫苗后 9年 ,检测正常人群 72 0名和 80 3名甲肝总抗体。血清检测法ELISA。结果　疫苗接种后人群总抗体阳性率有显著的提高。青少年及儿童 ( 18岁以下 )抗体阳性率由接种前的 2 9 84%提高到接种后的 6 4 15 % (P <0 0 1)。成人组( 2 5～ 35岁 )抗体阳性率从 78 9%到 84 5 % ,没有显著差别 (P >0 0 5 ) ,但未见有下降趋势。结论　儿童普及接种甲肝活疫苗后显著地提高了人群的总抗体水平 。Objective To evaluate the effect on HAV antibody levels of population in children vaccinated against viral hepatitis A.Methods Two groups of children from Jiaojiang city of Zhejiang Province were divided into seven subgroups according to ages respectively.720 subjects (group 1)were detected of anti HAV IgG levels in 1991,and 803 ones(group 2)were detected in 2000 after nine years of mass vaccination.ELISA method was used in serum test.Results Anti HAV IgG positive rate of whole population increased significantly.The positive rate in adolescents and children(<18 years old) increased from 29 84% to 64 15%(P<0 01);and in adults (25 to 35 years old)from 78 9% to 84 5% with no statistical significance(P>0 05).Conclusion HAV antibody levels of population in children significantly increase after vaccinating against viral hepatitis A,and no retrocession in age groups of susceptibility is found.

关 键 词：甲型肝炎 减毒活疫苗 总抗体 儿童 

分 类 号：R725.126.1[医药卫生—儿科]