中国北方汉族人细胞色素P4501 A1基因MspⅠ多态性的研究  

Study in genetic polymorphisms of cytochrome P4501A1 among Hans in North China

作　　者：刘振华[1] 刘平[1] 邵明[1] 陈彪[2] 

机构地区：[1]第一军医大学珠江医院神经内科,广州510282 [2]北京市宣武医院神经内科

出　　处：《解剖学研究》2002年第1期6-8,共3页Anatomy Research

基　　金：北京市卫生局重点学科资助项目"老年神经退行性疾病的基础与临床研究" ;北京市科委科技新星计划资助项目(95 4812 60 0 )

摘　　要：目的　探讨中国北方汉族人细胞色素P(cytochromeP ,CYP) 4 5 0 1A1基因MspⅠ多态性。方法　用聚合酶链反应 限制性片段长度多态性 (PCR RFLP)技术 ,分析了 172名北方汉族正常健康成人CYP1A1基因 3′端限制性内切酶MspⅠ位点的3种基因型 (A、B、C)的分布频率。结果　MspⅠ等位基因m1、m2分别占 6 0 8%、39 2 %。MspⅠ基因型A占 34 9% ,基因型B占 5 1 7% ,基因型C占 13 4 %。结论　本研究结果提示中国北方汉族人解毒酶CYP1A1基因存在MspⅠ多态性。Objective To assess the MspⅠ polymorphisms of CYP1A1 among Hans in North China.Methods Using polymerase chain reaction restriction fragment length polymorphism(PCR RFLP),three genotypes A,B and C in 3′ flanking region of CYP1A1 were studied in 172 Hans in North China.Results The frequencies of genotype A,B and C were 34.9%,51.7% and 13.4%,respecitively,while allele m1 and m2 were 60.8% and 39.2%,respectively.Conclusion Our results suggest that CYP1A1 has Msp Ⅰ polymorphisms among Hans in North China.

关 键 词：细胞色素P4501A1 等位基因 基因多态 汉族人 

分 类 号：R341[医药卫生—基础医学]