N,N′—双(3—羰甲氧苯基)脲的新合成方法  

A novel catalytic synthesis of N,N′-bis(3-carbomethoxy pheayl)urea

作　　者：王颖[1] 张善言[2] 

机构地区：[1]贵阳医学院药学系有机教研室,贵州贵阳550004 [2]四川大学化学系,四川成都610064

出　　处：《贵州师范大学学报（自然科学版）》2001年第4期55-56,共2页Journal of Guizhou Normal University：Natural Sciences

摘　　要：以间—硝基苯甲酸甲酯为底物 ,三乙胺为助催化剂 ,少量水为引发剂 ,经硒催化还原羰基化合成N ,N′—双(3—羰甲氧苯基 )脲 ,并对反应温度 ,反应时间及一氧化碳压力做了详细研究。所得N ,N′—双 (3—羰甲氧苯基 )脲的产率达 79%In this paper, a novel catalytic synthesis of N.N′--bis(3-carbomethoxy pheayl)urea is reported. We have synthesized the urea by reductive carbonylation.Selenium was used as a catalyst and triethylamine as a promoter. As an initiator, water was adopted. The reaction of M-Nitro-benzoic acid-methy ester with carbon monoxide was studied carefully.The optimun reaction temperature, reaction time, pressure of carbon monoxide were selected. Under optimum conditions, the urea was obtained in 79.0%yeild.

关 键 词：间-硝基苯甲酸甲酯 催化剂 还原羰化 合成 N N′-双(3-羰甲氧苯基)脲 反应温度 

分 类 号：O633.4[理学—高分子化学]