大鼠丘脑中央下核神经元对不同刺激的反应  

Responses of neurons in the thalamic nucleus submedius to different stimulation in the rat

作　　者：杨杰[1] 屈永才[1] 贾红[2] 

机构地区：[1]延安大学医学院生理学教研室,陕西延安716000 [2]西安交通大学医学院生理学教研室,陕西西安710061

出　　处：《延安大学学报（自然科学版）》2001年第4期61-64,共4页Journal of Yan'an University：Natural Science Edition

基　　金：国家自然科学基金资助项目 (39470 870 )

摘　　要：目的 :观察丘脑中央下核 (Sm)神经元对伤害性机械刺激 ,手针和电针刺激的反应特性。方法 :在麻醉大鼠 ,用玻璃微电极细胞外记录的方法 ,观察 Sm神经元对上述刺激的反应。结果 :大多数对手针刺激反应的神经元一般地也对伤害性皮肤或肌肉机械刺激发生反应 ,这些神经元也对电针刺激穴位发生反应 ,其反应随刺激强度、串长或重复次数的增加而加强 ,揭示针刺与伤害性机械刺激具有相同的属性。结论 :Sm可能在针感形成及针刺兴奋细纤维产生的镇痛中起重要作用。Objective:To observe the response characteristics of neurons in the thalamic nucleus submedius (Sm) to different stimuli in the rat.Methods:The experiments were conducted on 23 anaesthetize rats. The single unit activity was recorded extracellularly from the Sm with a glass micropipette, and the responses of neurons in Sm to noxious mechanical, needling and electrical acupuncture stimuli were observed.Results:Most(97 3%,46/58) of the neurons in Sm responded to needling acupuncture stimulation of points. In general, the neurons which responded to needling acupuncture stimulationalso responded to noxious cutaneous or muscle mechanical stimuli. These Sm neurons also responded to eletro-acupuncture stimulation, and the responses of neurons increased following the increase of the stimulation intensity, the train length and repetitive numbers. These results suggested that the properties of the acupuncture stimulation are similar to those of the noxious mechanical stimuli.Conclusion:It is possible that the Sm plays an important role in the needling sensative formation and the analgesia produced by acupuncture activation of the small afferent fibers.

关 键 词：伤害性刺激 手针刺激 电针刺激 “足三里”穴 中央下核 大鼠 神经元 丘脑 Sm 神经生理学 

分 类 号：R338.2[医药卫生—人体生理学]