二烯丙基硫醚化合物的合成  

Synthesis of Diallyl Mono-and Polysulfides

作　　者：楚勇[1] 赵敏政[2] 徐鸣夏[1] 

机构地区：[1]华西医科大学药学院,四川成都610041 [2]昆明贵金属研究所,云南昆明650221

出　　处：《合成化学》2001年第6期541-542,共2页Chinese Journal of Synthetic Chemistry

摘　　要：二烯丙基一硫醚 ( DS) ,二烯丙基二硫醚 ( DDS) ,二烯丙基三硫醚 ( DTS)和二烯丙基四硫醚 ( DTTS)等是大蒜提取液中的主要有效成分 ,具有十分广泛独特的生理药理活性。作者以甲酸、丙三醇为起始原料合成了这些化合物 ,烯丙基硫醚化合物总含量达 83% ,其中 DDS,DTS含量分别达 30 %。产物均 GC-MS鉴定确证。合成方法简单 ,原料易得 ,反应步骤少 。A number of pharmacologically and biologically active diallyl mono and polysulfides, the components of garlic extract, including diallyl sulfide(DS), diallyl disulfide(DDS), diallyl trisulfide(DTS) and diallyl tetrasulfide(DTTS) , were chemically synthesized for further study as new drug using commercially available reagents glycerol and methanoic acid as starting materials. Combined gas chromatography mass spectrometry and analysis of product showed that the abundant compounds of the product were mainly DS,DDS,DTS and DTTS, total amounts of their reached 83%.

关 键 词：二烯丙基一硫醚 二烯丙基多硫醚 甲酸 丙三醇 合成 

分 类 号：O623.82[理学—有机化学]