低密度脂蛋白结构研究进展  

ADVANCES IN STUDIES ON STRUCTURE OF LOW DENSITY LIPOPROTEINS

作　　者：卢玲[1] 何炳林[1] 袁直[1] 刘晓航[1] 

机构地区：[1]南开大学高分子化学研究所,吸附分离功能高分子材料国家重点实验室,天津300071

出　　处：《离子交换与吸附》2001年第5期363-368,共6页Ion Exchange and Adsorption

基　　金：973计划资助项目; 课题编号: G1999064707

摘　　要：摘要:本文对低密度脂蛋白(LDL)的形成、结构做了简单概述。LDL是由极低密度脂蛋白(VLDL)演化而成,对于其结构,目前为人们普遍接受的是乳状液颗粒模型。作为LDL中的主要载脂蛋白apoB-100,其一级结构已经为人们所知,而高级结构的研究也得出了不少有益的结论。此外,本文还对LDL上受体结合部位和LDL受体上LDL结合部位等方面做了简单叙述。Structure and formation of low density lipoproteins (LDLs) were summarized. LDLs were derived from very low density lipoprotein (VLDLs). Emulsion particle model was established for LDLs. Primary sequence of apolipoprotein B-100 was well known and many conclusions have been obtained about secondary and tertiary structure of apoB-100. In addition, receptor-binding domains on LDLs and LDL-binding domains on LDL receptors were also described.

关 键 词：低密度脂蛋白 载脂蛋白apoB-100 结构 冠心病 病因 LDL受体 肝素连接区 

分 类 号：R541.4[医药卫生—心血管疾病]