尿毒症毒素及其清除方法——兼论临床上的血液灌流治疗  

HAEMOPERFUSION IN THE CURE OF CHRONIC RENAL FAILURE

作　　者：王虹[1] 徐家毅[1] 袁直[1] 何炳林[1] 

机构地区：[1]吸附分离功能高分子材料国家重点实验室,南开大学高分子化学研究所,天津300071

出　　处：《离子交换与吸附》2001年第5期377-384,共8页Ion Exchange and Adsorption

基　　金：教育部跨世纪优秀人才培养计划;教育部重点科技项目(98098);天津市科学基金(983609711)

摘　　要：长期以来,慢性肾功能衰竭一直是一种严重的疾患.本文介绍了用以解释慢性肾功能衰竭病因的几个相关假说,并对其中的尿毒症毒素学说予以了特别的关注.依据这个假说,尿毒症毒素被分成了几大类;其中,分子量位于300～5000道耳顿的中分子毒素的作用尤其引人注目.通过对现有的几种治疗慢性肾功能衰竭方法进行比较,本文认为采用血液灌流的方法,以吸附剂来清除尿毒症患者体内滞留的中分子毒素有着其独到的优势.Chronic renal failure (CRF) has long been a fatal disease to the patients who suffer from it. In this article, some hypotheses for the causes of CRF were introduced and evaluated. Among these, the toxin-induced was favorable. In the light of this theory, uremic toxins were classified according to their molecular weights, and more attentions have been paid to the middle molecular substances (MMSs). By the comparison of some currently-available treatments to the CRF patients, the haemoperfusion way to clean up the accumulated uremic toxins stood out for its unique advantages.

关 键 词：慢性肾功能衰竭 尿毒症毒素 血液灌流 中分子毒素 吸附剂 治疗 

分 类 号：R692.5[医药卫生—泌尿科学] R457[医药卫生—外科学]