左氧氟沙星注射剂不良反应与合理性用药的前瞻性观察  

Adverse drug reaction and rational use of levofloxacin: A perspective study

作　　者：张政[1] 甄健存[2] 詹思延[1] 张威[2] 刘福珍[3] 徐艳霞[4] 梁雁[5] 王佩[6] 张慧英[7] 李占英[8] 

机构地区：[1]北京大学公共卫生学院流行病学教研室,100083 [2]北京大学积水潭医院 [3]首都医科大学同仁医院 [4]首都医科大学宣武医院 [5]北京大学第一医院 [6]北京大学人民医院 [7]北京大学第三医院 [8]首都医科大学朝阳医院

出　　处：《中华流行病学杂志》2001年第6期405-407,共3页Chinese Journal of Epidemiology

摘　　要：目的　了解住院病人使用左氧氟沙星注射剂的不良反应发生率和合理性用药。方法　前瞻性观察北京市 7家医院中使用左氧氟沙星注射剂的全部住院病人。结果　 2 6 6 1例用药者中发生不良反应 10 5例 ,不良反应发生率为 3.9% ,其中重度不良反应占 4.8% ,全部是二重感染。不良反应的发生与老龄、用药不合理、合并用药和既往过敏史有关。左氧氟沙星不合理用药占19 .9% ,集中于 6 0岁以上的老年人群。主要问题为用药时间不合理 (疗程过长或过短 )。结论　左氧氟沙星注射剂在临床上应用比较安全 ,但要注意合并用药问题和老年人的用药安全性。Objective To study the rate of adverse drug reaction(ADR) and the rational use of levofloxacin among in patients. Method All in patients treated with levofloxacin were prospectively observed in 7 hospitals of Beijing. Results One hundred and five ADR cases were found in 2 661 patients injected with levofloxacin. The ADR rate was 3.9 % while 4.8 % of them were classified as severe cases. All severe ADR cases had a nature of double infections. The ADR occurrence was related to older age, irrational drug use, combined medicine and allergic history. The rate of levofloxacin irrational use was 19.9 %, especially in the elderly population, due to too long or too short course of treatments. Conclusion Levofloxacin is viewed as a safe injection in clinical practice, however, combined medicine and elderly patients should be paid more attention when on administration of this medication. The irrational use of levofloxacin was recognized as one of the main reasons causing the increase of ADR.

关 键 词：左氧氟沙星 不良反应 合理性用药 前瞻性观察 

分 类 号：R181.35[医药卫生—流行病学]