兽药“8405”有效成份洗必太Chlorhexidinum及其代谢物残留的动态变化  

DYNAMICS OF CHLORHEXIDINUM-EFFECTIVE COMPONENT FROM ANIMAL MEDICINE "8405" IN RAT

作　　者：胡安畅[1] 胡建成[1] 赵润东[1] 张喜春[1] 毕振东[1] 张凌志[1] 李长明[1] 

机构地区：[1]沈阳农业大学

出　　处：《核农学报》1989年第1期43-47,共5页Journal of Nuclear Agricultural Sciences

摘　　要：采用G-T-洗必太研究了兽药新剂型“8405”的有效成份洗必太,及其代谢物在大白鼠主要脏器,组织,尿和血液中残留的变化。测定结果表明,连续注药三日后第2小时,在所观察的器官、组织和尿液中,发现有不同数量的洗必太存在。第240小时,在肝、肾、肌肉、脂肪体和尿液中,洗必太趋于消失。但是,直至第1080小时(第45天),在所观察的脏器、组织和尿液中,仍有洗必太的代谢物残留。Changes and residues of chlorhexidinum in internal organs, tissues, urine and blood of rat were studied by means of G-T-C22H30N10Cl2. The results showed that amounts of C22H30N10Cl2 in organs, tissues and urine were different at the 74th hour after injection. By the 240th hour, C22H30N10Cl2 in liver, kinney, muscle,adipose tissue and urine tended to disappear. However, at the 180th hour, small amounts of metabolites of C22H30N10Cl2 were still observed in the internal organs, tissues and urine. Therefore, the types of metabolites of C22H30N10Cl2 and their effects on the body should be further studied.

关 键 词：洗必太 放射性薄层 兽药 

分 类 号：S859.1[农业科学—临床兽医学]