甲基苯丙胺在豚鼠毛发中分布及转化的初步研究  

Study of distribution and metabolism of methamphetamine in hair of guinea pig

作　　者：姜宴[1] 沈敏[2] 赵子琴[1] 叶永红[1] 向平[2] 沈保华[2] 

机构地区：[1]复旦大学医学院法医学教研室,上海200032 [2]司法部司法鉴定科学技术研究所,上海200063

出　　处：《法医学杂志》2001年第4期214-217,共4页Journal of Forensic Medicine

基　　金：司法部九五重点攻关项目(司法通(1998)077号)

摘　　要：目的对甲基苯丙胺在豚鼠毛发中分布及转化机制进行初步研究。方法利用GC/MS,GC/NPD法,测定单次及多次给药豚鼠毛发中MAP、AP的含量变化过程,考察给药剂量与毛发中MAP、AP的含量间的关系,并研究毛发颜色对染毒豚鼠毛发中MAP、AP含量的影响。结果单次及多次给药豚鼠毛发中代谢产物AP均高于原体MAP,给药时间及给药剂量与毛发中MAP、AP的含量显著相关,同体豚鼠黑色毛发中的MAP、AP含量均明显高于棕色、白色毛发。结论给药方式、给药剂量及毛发颜色对豚鼠毛发中MAP、AP的含量均有显著影响。Objective To study the distribution and metabolism of methamphetamine in the hair of guinea pig.Methods Determination of methamphetamine and its metabolite amphetamine in hair was performed by GC/MS and GC/NPD. Concentration-time course of methamphetamine and amphetamine in hair of guinea were recorded. Relationship between hair color, administrated dose and drug concentration in hair were also discussed. Results The concentration of amphetamine is higher than the concentration of methamphetamine in the hair of guinea administrated a single dose or seven doses of methamphetamine. The concentration of methamphetamine and amphetamine were significantly related with administration dose and the incorporation rate into white and brown hair is much poorer than that of black hair. Conclution Administration methods, dose and the color of hair affect the concentration of methamphetamine and amphetamine.

关 键 词：甲基苯丙胺 苯丙胺 毛发 分布 转化 法医鉴定 

分 类 号：D919.4[医药卫生—法医学] R89[政治法律—法学]