神经元特异性烯醇化酶在新生儿HIE及高压氧治疗的临床研究  

The clinical significance of hyperbaric oxygen therapy in hypoxic ischemic encephalopathy and the dynamic change during hyperbaric oxygen therapy

作　　者：杨秋格[1] 董志芬 檀国军[1] 王秀霞[1] 罗克娴[1] 

机构地区：[1]河北医科大学第二医院儿科,石家庄050000 [2]河北省赵县人民医院妇产科

出　　处：《中国优生与遗传杂志》2001年第6期29-29,38,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的 :动态观察神经元特异性烯醇化酶在新生儿缺氧缺血性脑病 (HIE)时及高压氧治疗前后水平的变化 ,以探讨在临床中的意义。方法 :应用双抗体夹心法测定HIE病人于入院 2 4h、3d、5d及高压氧治疗前后血清中NSE浓度与对照组比较。结果 (1)ME患者 2 4h、3d时血清NSE水平显著高于对照组 ,P <0 .0 5 ,5d时与对照组无差异 ,P =0 .75 6。(2 ) 2 4h血清NSE含量显著高于 3d、5d ,P =0 .0 0 0 2 ,3d时血清NSE含量显著高于 5d ,P =0 .0 38。 (3)高压氧治疗后血清中NSE含量显著降低 ,P =0 .0 2 7。结论 (1)HIE时血清中NSE含量明显增高 ,且其升高程度与病情危重程度密切相关。 (2 )高压氧对治疗HIE有较好的效果 ,且可改善预后 。Objective:To investigate dynamically the change of content of neuro-specific enolase in hypoxic ischemic encephalopathy and during the course hyperbaric oxygen therapy by means of discussing its clinical value.method:To measure the serum concentration of NSE on 24h?3d?5d of being in hospital and before and after hyperbaric oxygen therapy by using double antibody method.Meanwhile,we compared the contents with control group.results:(1):the serum concentration of HIE patients in 24h?3d were higher significantly than control group,P<0.05,but there was no difference between that of in 5d and in control group,P=0.756;(2)the contents of NSE patients in 24h was higher significantly than that of in 3d?5d,P=0.0002,which of in 3d was higher than in,P=0.038;(3)the contents of NSE patients decreased notably in hyperbaric oxygen post-treatment P=0.027.Conclusion;(1)the serum level in Neonatal hypoxic ischemic encephalopathy increased highly,and thee was closely correlation between its step-up degree and patients condition;(2)hyperbaric oxygen therapy was effective for HIE treatment as well as improving the prognosis of HIE,but we propose that the course should be within five times.

关 键 词：神经元特异性烯醇化酶 新生儿 缺氧缺血性脑病 高压氧治疗 

分 类 号：R722.121[医药卫生—儿科]