挤压综合征大鼠血清酶浓度变化的初步研究  

The preliminary study on change of serum enzyme level in crush syndrome rat

作　　者：刘水平[1] 陈玉川[1] 郭薇[1] 成建定[1] 

机构地区：[1]中山医科大学法医病理教研室,广东广州510080

出　　处：《法医学杂志》2001年第4期205-206,共2页Journal of Forensic Medicine

摘　　要：目的观察挤压伤大鼠血清肌酸激酶(CK)、肌酸激酶心肌同功酶(CK-MB)浓度的变化,阐明肢体挤压伤大鼠早期是否存在心脏损伤。方法复制挤压伤大鼠动物模型,全自动生化分析仪检测血清CK、CK-MB浓度的变化。结果挤压伤后12h,血清CK、CK-MB浓度显著升高,并持续48h以上。结论肢体挤压伤早期可能有心脏损伤的存在。Objective To study the changes of serum creatinine kinase(CK) and its cardiac-specific isoenzyme compound(CK-MB) levels in crush injury rats.Methods Crush injury was produced in SD rats,the serum levels of CK and CK-MB were studied by automated biochemical analyzer.Results The levels of plasma CK and CK-MB were much higher in crush injury rats than those of the control group.Conclusions Cardiomyocyte injury may be induced in the early stage of crush injury rats.

关 键 词：挤压综合征 肌酸激酶 肌酸激酶心肌同功酶 法医 

分 类 号：D919.4[医药卫生—法医学] R89[政治法律—法学]