维生素K对尾悬吊大鼠骨代谢的影响  

Effects of Vitamin K on Bone Metabolism in Tail-suspended Rats.

作　　者：黄大威[1] 万玉民[1] 谢力勤[1] 马永洁[1] 梁文彬[1] 史之祯[1] 

机构地区：[1]航天医学工程研究所,北京100094

出　　处：《航天医学与医学工程》2001年第5期346-349,共4页Space Medicine & Medical Engineering

摘　　要：目的探讨维生素K对模拟失重大鼠骨质的影响 ,为失重骨丢失的防护提供实验依据。方法将SD雄性大鼠分为 3组 ,自由对照组 (FAC) ,悬吊对照组 (SC) ,维生素K悬吊组 (SVK) ( 5 0mg kgweight d) ,每组 9只。每天灌胃给药 ,实验期为 2 1d。观察维生素K对尾悬吊大鼠血清骨钙素 (BGP)、骨生物力学、矿盐含量、一氧化氮 (NO)含量及碱性磷酸酶 (ALP)活性含量的影响。结果与SC比较 ,SVK血清总BGP和结合型BGP ,股骨和胫骨矿盐含量 ,股骨生物力学 ,胫骨ALP活性含量均显著增加 ;股骨干NO含量明显减少。结论维生素K可改善尾悬吊大鼠的骨代谢和骨结构 ,减少骨丢失 ,提高骨生物力学性能 。Objective To study the effects of vitamin K on bone metabolize in simulated weightlessness rats. Method Male SD rats were divided into three groups(n=9):the free active control (FAC),the tail suspended control (SC), and the tail suspended group treated with vitamin K (SVK) (50 mg/kg weight/d). The experiment lasted for 3 weeks. Bone biomechanical properties, bone mineral contents(BMC) and bone biochemical markers of bone metabolism were determined. Result Compared with SC, total and bound bone gla protein(BGP) of serum , BMC of the femur and tibia, femoral mechanical properties, ALP activity of tibia all increased significantly; while NO content of femoral trunk decreased significantly. Conclusion Vitamin K improved the bone metabolism and bone structure, decreased bone loss,increased bone biomechanical properties, decreased catagmatic fatalness. It proved that vitamin K prevented bone loss of simulated weightlessness rats.

关 键 词：模拟失重 维生素K 骨钙素 骨代谢 大鼠 

分 类 号：R852.22[医药卫生—航空、航天与航海医学] R977.26[医药卫生—临床医学]