药物对高原移居者睡眠呼吸紊乱警觉性作用初步研究  

Effects of Hongjingtian (Chinese Herb) and Acetarolamide on the Vigilance of High Attitude Immigrants with Sleep Disordered Breathing

作　　者：马勇[1] 张西洲[1] 王引虎[1] 哈振德[1] 朱永安[1] 王伟[1] 崔建华[1] 张素萍[1] 

机构地区：[1]新疆军区高山病研究所,844900

出　　处：《中国心理卫生杂志》2001年第4期268-270,共3页Chinese Mental Health Journal

摘　　要：目的 :应用心理生理测验的途径检测探索高海拔地区抗低氧药物对移居者睡眠呼吸紊乱(SDB)警觉性的作用。方法 :选择驻守在海拔 5 3 80米高原 12个月青年士兵 2 4人 ,随机分为甲、乙两组 ,采用DDX -2 0 0型电脑多功能心理生理能力测试仪和ASC -5 45型血氧仪 ,监测前晚 11 3 0时和早晨 8 2 0时静息状态下的脑功能和血氧饱和度 (SaO2 ) ,衡量其警觉性。甲组口服三普红景天胶囊 ,乙组口服乙酰唑胺片 ;均一次服药 2 5天后 ,重复监测前晚和早晨静息状态下的脑功能及SaO2 ,并进行服药前后的对比评定。结果 :甲乙两组服药前晚、晨SaO2 比较相近似 ,无显著性差异 (p >0 0 5 )、服药后甲组晚、晨SaO2 显著高于服药前 (p <0 0 5 ) ;服药后乙组晨SaO2 显著高于服药前 (p <0 0 1)。甲、乙组服药前晚、晨比较 ,视觉注意分配无显著性差异 (p >0 0 5 ) ;缺失记忆测验、甲组晚晨与乙组比较错误次数显著增多 (p <0 0 1) ,服药后亦相同。服药后甲组视觉注意分配测验晚操作总次数、正确次数 ,晨正确次数显著高于服药前 (p <0 0 1或p <0 0 5 ) ,操作平均时间显著低于服药前 (p <0 0 1) ;缺失记忆测验晚错误次数显著多于服药后 (p <0 0 1) ;服药后乙组晚视觉注意分析总次数、正确次数显著多于服药前 (p <0 0 1或pObjective:To Effects of Hongjingtian (Chinese Herb) and Acetarolamide on the vigilance of high attitude immigrants with sleep disordered breathing Methods: To determine the brain functions by vision-attention-distribute test of 24 young soldiers living on 5380 meters above sea level for 1 year and test their blood oxygen saturation (SaO 2) before going to sleep and the next morning The soldiers were randomly divided into two groups, group A received Hongjingtian capsules and group B acetarolamide The tests were repeated after 25 days medication Results: After taking the two medicines for 25 days, the SaO 2 increased obviously (p<0 05 and p<0 01 respectively) The average operate time decreased notably in both groups (p<0 01) In the memory-lose test, the times of wrong decreased after medication (p<0 05) But there was no difference of the above results between the two medicines Conclusion: Both Hongjingtian (Chinese Herb) and Acetarolamide can improve the vigilance of high attitude immigrants with sleep disordered breathing

关 键 词：睡眠呼吸紊乱 警觉性 高原 低氧 红景天 乙酰唑胺 

分 类 号：R594.305[医药卫生—内科学]