游泳延缓小鼠衰老的神经内分泌机制  

Neuroendocrine mechanisms of the aging retair induced by swimming in mice

作　　者：何海蓉[1] 张石宁[2] 李萍[3] 孙秀兰[1] 田苏平[1] 陈启盛[1] 

机构地区：[1]南京医科大学生理学药理学系,南京210029 [2]南京医科大学脑科医院神经生化研究所,南京210029 [3]徐州医学院生理学教研室,徐州221009

出　　处：《基础医学与临床》2001年第6期563-565,共3页Basic and Clinical Medicine

基　　金：江苏省教委自然科学基金 (GW970 0 97)

摘　　要：探讨适宜游泳应激对D 半乳糖致衰老小鼠抗衰老作用的神经内分泌调节机制。实验分为对照组、适宜应激组、D 半乳糖致衰老组和衰老应激组。检测下丘脑NE、5 HT ,以及血浆ACTH、皮质醇的含量。适宜应激组NE和皮质醇含量明显高于对照组 ,而 5 HT和ACTH含量无明显变化 ,5 HT/NE比值明显减少 ;D 半乳糖衰老组NE和ACTH含量明显低于对照组 ,血浆皮质醇含量降低不明显 ,而 5 HT含量和 5 HT/NE比值明显升高。但是 ,衰老应激组NE、ACTH和皮质醇含量均明显高于衰老组 ,而 5 HT含量和 5 HT/NE比值明显降低 ,并与对照组相近。提示神经内分泌机制可能参与适宜游泳应激对小鼠衰老进程的延缓。To study the effect of proper swiming stress on the aging mice' neuroendocrine function The mice were divided into 4 groups:the control, the swiming stress (swimming for 15min at 18℃ daily), the aging induced by D galactose (0 12mg/g·d), and the aging plus stress Eight weeks later, the contents of noradrenaline(NE), serotonin(5 HT) in the hypothalamus, adrenocorticotropine(ACTH) and cortisol in blood were measured Compared with the control, the stress group has contents of NE and cortisol increased, 5 HT and ACTH showed no significant changes. The ratio of 5 HT/NE decreased; and in the aging group the content of NE and ACTH significantly decreased, cortisol showed no significant decrease, 5 HT and 5 HT/NE significantly increased In the aging plus stress group the content of NE, ACTH and cortisol were significantly increased while 5 HT and 5 HT/NE were significantly decreased compared with the aging group. It seemed that proper swiming stress might delay aging process by improving the aging mice' neuroendocrine function

关 键 词：游泳 D-半乳糖 衰老 神经内分泌 

分 类 号：R338.2[医药卫生—人体生理学]